Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure
Smith C, Sun D, Hoegler C, Roth B, Zhang X, Zhao G, Xu X, Kobari Y, Pritchard K, Sessa W, Hintze T. Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure. Circulation Research 1996, 78: 58-64. PMID: 8603506, DOI: 10.1161/01.res.78.1.58.Peer-Reviewed Original ResearchConceptsHeart failureCyclooxygenase-1Von Willebrand factorPacing-induced heart failureVentricular end-diastolic pressureEndothelial cellsEndothelium-dependent responsesEnd-diastolic pressureLeft ventricular pacingPeripheral blood vesselsDiastolic pressureVentricular pacingThoracic aortaClinical signsMongrel dogsWestern blottingBlood vesselsWillebrand factorArbitrary unitsEcNOSTotal RNADogsPresent studyFailureCells