The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen
Hecker M, Sessa W, Mitchell J, Änggård E, Vane J. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen. Journal Of Cardiovascular Pharmacology 1991, 17: s19-s24. DOI: 10.1097/00005344-199117003-00005.Peer-Reviewed Original ResearchCultured endothelial cellsBiosynthesis of EDRFRelease of EDRFEndothelial cellsNitric oxideKrebs solutionComplete urea cycleImportant regulatory factorCellular regulationExcess nitrogenVariety of cellsRegulatory factorsBiosynthesisPhysiologic buffer solutionFlow-induced releaseRelaxing factorsCytotoxic macrophagesIntracellular sourcesBrain synaptosomesEDRF biosynthesisEDRFIntracellular concentrationTransient riseCalcium ionophoreGln