1995
The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(∗)
Sessa W, Garca-Cardea G, Liu J, Keh A, Pollock J, Bradley J, Thiru S, Braverman I, Desai K. The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(∗). Journal Of Biological Chemistry 1995, 270: 17641-17644. PMID: 7543089, DOI: 10.1074/jbc.270.30.17641.Peer-Reviewed Original ResearchConceptsHEK-293 cellsHeterologous expression systemEndothelial nitric oxide synthaseNovel GolgiGolgi associationExpression systemIntracellular signalsCultured endothelial cellsGolgiIntact blood vesselsEnzymeParticulate enzymeProteinEndothelial cellsCellsSynthaseNitric oxide synthaseOxide synthaseBlood vesselsCompartmentalizationNitric oxideTarget
1991
The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen
Hecker M, Sessa W, Mitchell J, Änggård E, Vane J. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen. Journal Of Cardiovascular Pharmacology 1991, 17: s19-s24. DOI: 10.1097/00005344-199117003-00005.Peer-Reviewed Original ResearchCultured endothelial cellsBiosynthesis of EDRFRelease of EDRFEndothelial cellsNitric oxideKrebs solutionComplete urea cycleImportant regulatory factorCellular regulationExcess nitrogenVariety of cellsRegulatory factorsBiosynthesisPhysiologic buffer solutionFlow-induced releaseRelaxing factorsCytotoxic macrophagesIntracellular sourcesBrain synaptosomesEDRF biosynthesisEDRFIntracellular concentrationTransient riseCalcium ionophoreGln
1990
Inhibition by l‐glutamine of the release of endothelium‐derived relaxing factor from cultured endothelial cells
Hecker M, Mitchell J, Swierkosz T, Sessa W, Vane J. Inhibition by l‐glutamine of the release of endothelium‐derived relaxing factor from cultured endothelial cells. British Journal Of Pharmacology 1990, 101: 237-239. PMID: 2257431, PMCID: PMC1917688, DOI: 10.1111/j.1476-5381.1990.tb12693.x.Peer-Reviewed Original Research