2023
Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology
Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAtopic dermatitisSkin diseasesInflammatory skin diseaseInflammatory skin conditionImmunologic biomarkersImmune biomarkersPersonalized medicineInflammatory dermatosesImmunologic approachesTherapy selectionSkin conditionsSingle-cell RNA sequencingMolecular profilingBiomarkersTissue stainingPsoriasisDermatitisDiseaseDermatologyRNA sequencingMedicineCurettageDermatosesTherapyPersonalized classificationIL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies
Chen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C, Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. JID Innovations 2023, 3: 100189. PMID: 37205304, PMCID: PMC10186614, DOI: 10.1016/j.xjidi.2023.100189.Peer-Reviewed Original ResearchMycosis fungoides palmaris et plantarisPalmoplantar psoriasisNonacral sitesPalmoplantar eczemaMRNA expressionAcral skinIL-13 expressionPalmaris et plantarisDiagnostic skin biopsyDermatopathology databaseIL-17AHistopathologic featuresClinical managementBiopsy specimensSkin biopsiesCytokine biomarkersUseful biomarkerEczemaPsoriasisDiagnostic clarityMRNA stainingDermatosesBiomarkersSitu hybridizationSkinPsoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program
Joel M, Fan R, Damsky W, Cohen J. Psoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program. Archives Of Dermatological Research 2023, 315: 1823-1826. PMID: 36707438, DOI: 10.1007/s00403-023-02539-z.Peer-Reviewed Original ResearchConceptsAllergic rhinitisUS adultsUs Research ProgramCommon chronic inflammatory diseaseMultivariable logistic regression modelNationwide longitudinal cohortImmunopathogenesis of psoriasisBody mass indexChronic inflammatory diseaseCases of asthmaCross-sectional studyLogistic regression modelsMultivariable analysisSmoking statusMass indexInflammatory pathwaysSubgroup analysisInflammatory diseasesLongitudinal cohortHigh prevalenceAsthmaPsoriasisPotential associationDiverse cohortSociodemographic variables
2022
Dupilumab‐induced psoriasis in the setting of pembrolizumab therapy: an analysis of cytokine expression
Ahmad M, Murphy M, Damsky W, Leventhal J. Dupilumab‐induced psoriasis in the setting of pembrolizumab therapy: an analysis of cytokine expression. International Journal Of Dermatology 2022, 62: e424-e426. PMID: 36468831, DOI: 10.1111/ijd.16538.Peer-Reviewed Original ResearchAssociation of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program
Murphy M, Leasure A, Damsky W, Cohen J. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Archives Of Dermatological Research 2022, 315: 1439-1441. PMID: 36436011, DOI: 10.1007/s00403-022-02488-z.Peer-Reviewed Original ResearchConceptsCross-sectional studyMatched cross-sectional studyAssociation of sarcoidosisCoexistence of sarcoidosisCommon genetic susceptibilitySimilar immunopathogenesisCardiopulmonary symptomsPsoriasis patientsInflammatory skinMultivariable analysisSystemic diseasePsoriasis casesProgram databaseImmune responseSarcoidosisPsoriasisUs Research ProgramPotential associationGenetic susceptibilityDiseaseImmunopathogenesisAssociationSame individualFurther researchTh1