Altered Natural Killer Cells in Type 1 Diabetic Patients
Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D. Altered Natural Killer Cells in Type 1 Diabetic Patients. Diabetes 2007, 56: 177-185. PMID: 17192480, DOI: 10.2337/db06-0493.Peer-Reviewed Original ResearchConceptsType 1 diabetesBlood NK cellsType 1 diabetic patientsNK cellsNatural killer cellsDiabetic patientsNatural killerControl subjectsReduced activity of NK cellsKiller cellsDecreased expression of NKG2DActivity of NK cellsPatients relative to control subjectsDevelopment of type 1 diabetesHuman type 1 diabetesEarly onset of diabetesExpression of NKG2DType 1 diabetes pathogenesisGamma interferon expressionDuration of diseaseKIR gene haplotypesOnset of diabetesKIR2DS3 geneNOD miceGamma interferon