Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
Villaseñor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15854-15859. PMID: 18836079, PMCID: PMC2572966, DOI: 10.1073/pnas.0808069105.Peer-Reviewed Original ResearchConceptsPeripheral-tissue antigensMedullary epithelial cellsPeripheral tissue antigensPta geneSelf-tolerant T cell repertoireTranscription start sitePeripheral cellsThymic medullary epithelial cellsCoexpression of genesT cell repertoireRepertoire of antigensEpithelial cell lineagesStart siteTranscriptional regulationBiallelic transcriptionThymic epitheliumPresenting antigensEctopic expressionCell repertoireGenesAIRE functionEpithelial cellsAntigenSingle-cell PCRCell lineages