2022
Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery
MacCuaig W, Samykutty A, Foote J, Luo W, Filatenkov A, Li M, Houchen C, Grizzle W, McNally L. Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery. Pharmaceutics 2022, 14: 969. PMID: 35631554, PMCID: PMC9148138, DOI: 10.3390/pharmaceutics14050969.Peer-Reviewed Original ResearchPre-existing lesionsIntravenous injectionChronic injectionsTreatment groupsBlood chemistryComplete blood count analysisStandard blood chemistryBlood count analysisMultiple intravenous injectionsModerate exacerbationsAdministered treatmentVascular conditionsMinor exacerbationsVital organsFurther evaluationTreatment of diseasesMinimal toxicityTranslational potentialNano-delivery systemsExacerbationFurther studiesInjectionLesionsMiceVivo toxicity
2008
Association of Mycoplasma arthritidis Mitogen with Lethal Toxicity but Not with Arthritis in Mice
Luo W, Yu H, Cao Z, Schoeb T, Marron M, Dybvig K. Association of Mycoplasma arthritidis Mitogen with Lethal Toxicity but Not with Arthritis in Mice. Infection And Immunity 2008, 76: 4989-4998. PMID: 18779340, PMCID: PMC2573368, DOI: 10.1128/iai.00667-08.Peer-Reviewed Original ResearchConceptsCBA/J miceLethal toxicityHuman rheumatoid arthritisSeverity of arthritisMycoplasma arthritidis mitogenChronic arthritisRheumatoid arthritisHistopathological studyJ miceSystemic injectionDBA/2J miceArthritisPathogenic significanceMiceMitogenic activityMycoplasma arthritidisToxicityAcutePathogenesisSuperantigensArthritogenicityDiseaseSeverity