2021
An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer
Zhou Z, Zhang J, Xu C, Yang J, Zhang Y, Liu M, Shi X, Li X, Zhan H, Chen W, McNally L, Fung K, Luo W, Houchen C, He Y, Zhang C, Li M. An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer. EBioMedicine 2021, 65: 103271. PMID: 33714027, PMCID: PMC7966986, DOI: 10.1016/j.ebiom.2021.103271.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsPancreatic ductal adenocarcinomaImmune evasionCheckpoint inhibitorsOverall survivalImmune infiltrationPancreatic cancerTumor aggressivenessM6A regulatorsSomatic copy number alterationsT cell exhaustionDismal overall survivalMutation profilesN6-methyladenosine regulatorsHigh response ratePancreatic cancer prognosisClassical pancreatic ductal adenocarcinomaCancer CenterColorectal cancerTumor recurrenceDuctal adenocarcinomaM6AscoreBreast cancerTreatment responseCell exhaustion
2018
CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment
Luo W, Fedda F, Lynch P, Tan D. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment. Frontiers In Pharmacology 2018, 9: 1421. PMID: 30568591, PMCID: PMC6290068, DOI: 10.3389/fphar.2018.01421.Peer-Reviewed Original ResearchInternational Gastric Cancer Linkage ConsortiumHereditary diffuse gastric cancer syndromeGastric cancer syndromeGastric cancerMutation carriersGermline mutationsCancer syndromesCommon germline mutationsProphylactic total gastrectomyInvasive lobular carcinomaOptimal surveillance strategySporadic diffuse gastric cancerRecent histologic studiesFamilial gastric cancerDiffuse gastric cancerMost cancer mortalityTotal gastrectomySurgical candidatesDismal prognosisCommon malignancyHistological findingsLobular carcinomaCancer mortalityColorectal cancerColorectal adenocarcinoma