2004
Rapid timescale processes and the role of electronic surface coupling in the photolysis of diatomic ligands from heme proteins
Champion P, Rosca F, Ionascu D, Cao W, Ye X. Rapid timescale processes and the role of electronic surface coupling in the photolysis of diatomic ligands from heme proteins. Faraday Discussions 2004, 127: 123-135. PMID: 15471342, DOI: 10.1039/b316440c.Peer-Reviewed Original ResearchConceptsVibrational coherenceExcited state potential energy surfacesState potential energy surfaceLaser excitationSpin-forbidden naturePotential energy surfaceIron-histidine modeHeme protein myoglobinUltrafast time scaleIron spin stateRaman inactive modesFemtosecond laser excitationResonance Raman measurementsDiatomic ligandsEnergy surfaceGeminate recombinationUnpaired electronLigand dissociationSurface crossingsIron atomsUnphotolyzed stateVibrational frequenciesField interactionsExcited statesProtein myoglobin
2001
Water Penetration and Binding to Ferric Myoglobin †
Cao W, Christian J, Champion P, Rosca F, Sage J. Water Penetration and Binding to Ferric Myoglobin †. Biochemistry 2001, 40: 5728-5737. PMID: 11341838, DOI: 10.1021/bi010067e.Peer-Reviewed Original ResearchConceptsH2O bindingHeme pocketHydrogen bondsHis-64Heme ironFlash photolysis investigationsPhotodissociation of NOFerric heme proteinsH2O ligandsWater moleculesNO photolysisHorse heart metmyoglobinHeme proteinsCO escapeBound waterRebinding rateSmall moleculesH2OPhotolysisDissociation constantBondsHydrogenHemeMoleculesPhysiological NO concentrations