Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses
Li W, Avey D, Fu B, Wu J, Ma S, Liu X, Zhu F. Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses. Journal Of Virology 2016, 90: 5329-5342. PMID: 27009954, PMCID: PMC4934757, DOI: 10.1128/jvi.02675-15.Peer-Reviewed Original ResearchConceptsKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusImmune evasion functionsViral particlesKSHV replicationTegument proteinsInfectious progeny virusInfectious viral particlesPrimary infectionSpecific monoclonal antibodiesExtracellular virionsViral life cycleImmune evasionKSHV life cycleTherapeutic interventionsViral replicationNovel targetKSHV lytic replicationMonoclonal antibodiesCytosolic DNAReduced virion productionLytic replicationProgeny virusVirion proteinsVirion production