2023
Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis
Hudson J, Cruickshank M, Quinton R, Aucott L, Wu F, Grossmann M, Bhasin S, Snyder P, Ellenberg S, Travison T, Brock G, Gianatti E, van der Schouw Y, Emmelot-Vonk M, Giltay E, Hackett G, Ramachandran S, Svartberg J, Hildreth K, Antonic K, Tenover J, Tan H, Ho Chee Kong C, Tan W, Marks L, Ross R, Schwartz R, Manson P, Roberts S, Skovsager Andersen M, Velling Magnussen L, Aceves-Martins M, Gillies K, Hernández R, Oliver N, Dhillo W, Bhattacharya S, Brazzelli M, Jayasena C. Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis. The Lancet Healthy Longevity 2023, 4: e561-e572. PMID: 37804846, DOI: 10.1016/s2666-7568(23)00169-1.Peer-Reviewed Original ResearchConceptsBenefits of testosterone treatmentData meta-analysisParticipant data meta-analysisSerum total testosteroneBaseline serum total testosteroneMild erectile dysfunctionTestosterone treatmentParticipant dataMeta-analysisPatient ageIIEF-15Sexual functionTotal testosteroneErectile dysfunctionSymptomatic benefitLow testosteroneSerum total testosterone concentrationsAging Male Symptoms ScoreSystematic reviewBaseline serum testosteroneHealth Technology Assessment programmeOlder menIIEF-15 scoreTestosterone replacement therapyMinimal clinically important difference
2022
Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis
Hudson J, Cruickshank M, Quinton R, Aucott L, Aceves-Martins M, Gillies K, Bhasin S, Snyder P, Ellenberg S, Grossmann M, Travison T, Gianatti E, van der Schouw Y, Emmelot-Vonk M, Giltay E, Hackett G, Ramachandran S, Svartberg J, Hildreth K, Antonic K, Brock G, Tenover J, Tan H, Kong C, Tan W, Marks L, Ross R, Schwartz R, Manson P, Roberts S, Andersen M, Magnussen L, Hernández R, Oliver N, Wu F, Dhillo W, Bhattacharya S, Brazzelli M, Jayasena C. Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis. The Lancet Healthy Longevity 2022, 3: e381-e393. PMID: 35711614, PMCID: PMC9184259, DOI: 10.1016/s2666-7568(22)00096-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedHeart FailureHumansHypogonadismMaleMyocardial InfarctionSystematic Reviews as TopicTestosteroneConceptsRisk of biasMeta-analysisStudy designSystematic reviewInclusion criteriaCochrane Database of Systematic ReviewsCochrane risk of bias toolDatabase of Systematic ReviewsRisk of bias toolMEDLINE In-Process & Other Non-Indexed CitationsIn-Process & Other Non-Indexed CitationsTwo-stage meta-analysisCharacteristics of interventionsOther Non-Indexed CitationsMeta-analysis of randomised controlled trialsOne-stage meta-analysisFull-text screeningRandomised controlled trialsNon-Indexed CitationsCardiovascular eventsAggregate data meta-analysisCoronary heart diseaseData meta-analysisPeer-reviewed publicationsCochrane Controlled Trials Register
2013
Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study
Tan W, Low W, Ng C, Tan W, Tong S, Ho C, Khoo E, Lee G, Lee B, Lee V, Tan H. Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study. BJU International 2013, 111: 1130-1140. PMID: 23651425, DOI: 10.1111/bju.12037.Peer-Reviewed Original ResearchConceptsProstate-specific antigenTestosterone undecanoateTestosterone deficiencyTreatment armsAdverse eventsSex hormone-binding globulinIntramuscular testosterone undecanoateCommon adverse eventsIncreased serum testosteroneHormone-binding globulinLiver function testsCessation of treatmentFasting blood glucosePhysical examination resultsRandomised controlled studySite of injectionTU injectionsPlacebo armSerum TTSerum testosteroneSpecific antigenAdverse reactionsLipid profileFunction testsControlled studies
2011
The triad of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome: findings from a multi-ethnic Asian men study (The Subang Men’s Health Study)
Tan W, Ng C, Khoo E, Low W, Tan H. The triad of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome: findings from a multi-ethnic Asian men study (The Subang Men’s Health Study). The Aging Male 2011, 14: 231-236. PMID: 22115177, DOI: 10.3109/13685538.2011.597463.Peer-Reviewed Original ResearchConceptsEtiology of erectile dysfunctionTestosterone deficiency syndromeFasting blood glucoseMetabolic syndromeMS componentsSelf-reported medical problemsDeficiency syndromeErectile dysfunctionInternational Index of Erectile FunctionSocio-demographic dataIndex of Erectile FunctionElevated fasting blood glucoseModerate-severe EDPredictors of EDElevated blood pressureHigher disease burdenMultivariate regression analysisAge of menIIEF-5Erectile functionDisease burdenPhysical examinationInternational IndexLipid profileUrban settings