2023
International Bladder Cancer Group Intermediate-risk Nonmuscle-invasive Bladder Cancer Scoring System Predicts Outcomes of Patients on Active Surveillance
Tan W, Contieri R, Buffi N, Lughezzani G, Grajales V, Soloway M, Casale P, Hurle R, Kamat A. International Bladder Cancer Group Intermediate-risk Nonmuscle-invasive Bladder Cancer Scoring System Predicts Outcomes of Patients on Active Surveillance. Journal Of Urology 2023, 210: 763-770. PMID: 37535836, DOI: 10.1097/ju.0000000000003639.Peer-Reviewed Original ResearchTransurethral resection of bladder tumorResection of bladder tumorNonmuscle-invasive bladder cancerTransurethral resectionBladder tumorsActive surveillanceBladder cancerScoring systemNonmuscle-invasive bladder cancer patientsAbsence of gross hematuriaMultivariate Cox proportional hazards analysisRisk factorsNonmuscle-invasive bladder tumorsNegative urinary cytologyCox proportional hazards analysisMedian follow-upMultivariate Cox regressionBladder cancer patientsProportional hazards analysisUrinary cytologyGross hematuriaT stageLandmark time pointsFollow-upCox regression
2022
Adjuvant Intravesical Chemohyperthermia Versus Passive Chemotherapy in Patients with Intermediate-risk Non–muscle-invasive Bladder Cancer (HIVEC-II): A Phase 2, Open-label, Randomised Controlled Trial
Tan W, Prendergast A, Ackerman C, Yogeswaran Y, Cresswell J, Mariappan P, Phull J, Hunter-Campbell P, Lazarowicz H, Mishra V, Rane A, Davies M, Warburton H, Cooke P, Mostafid H, Wilby D, Mills R, Issa R, Kelly J. Adjuvant Intravesical Chemohyperthermia Versus Passive Chemotherapy in Patients with Intermediate-risk Non–muscle-invasive Bladder Cancer (HIVEC-II): A Phase 2, Open-label, Randomised Controlled Trial. European Urology 2022, 83: 497-504. PMID: 35999119, DOI: 10.1016/j.eururo.2022.08.003.Peer-Reviewed Original ResearchConceptsIntermediate-risk non-muscle-invasive bladder cancerNon-muscle-invasive bladder cancerDisease-free survivalAdverse eventsBladder cancerMitomycin CChemotherapy instillationOpen-labelControl armAdjuvant intravesical chemotherapyProgression-free survivalPhase 2 randomised controlled trialIntention-to-treat analysisLow gradePer-protocol analysisChemohyperthermia groupIntravesical chemotherapyUrinary cytologyHeated chemotherapyOverall survivalWeekly instillationsTumor resectionPrimary endpointRandomised controlled trialsChemohyperthermia
2018
Does urinary cytology have a role in haematuria investigations?
Tan W, Sarpong R, Khetrapal P, Rodney S, Mostafid H, Cresswell J, Watson D, Rane A, Hicks J, Hellawell G, Davies M, Srirangam S, Dawson L, Payne D, Williams N, Brew‐Graves C, Feber A, Kelly J, Sridhar A, Lamb B, Ocampo F, McBain H, Baillie K, Middleton K, Knight H, Maher S, Pathmanathan B, Harmathova A, Pelluri S, Pati J, Cossons A, Scott C, Madaan S, Bradfield S, Wakeford N, Dann, Cook J, Cornwell M, Mills R, Thomas, Reyner S, Vallejera G, Adeniran P, Masood S, Whotton N, Dent K, Pearson S, Hatton J, Newton M, Hheeney E, Green K, Evans S, Rogers M, Gupwell K, ley S, Brown A, McGrath J, Lunt N, Hill P, inclair A, Paredes‐Guerra A, Holbrook B, Ong E, Wardle H, Wilson D, Bayles A, Fennelly R, Tribbeck M, Ames K, Taylor J, Edmunds E, Moore J, Mckinley S, Nolan T, peed A, Tunnicliff A, Fossey G, Williams A, George M, Hutchins I, Einosas R, Richards A, Henderson A, Appleby B, Kehoe L, Gladwell L, Drakeley S, Davies J, Krishnan R, Roberts H, Main C, Jain S, Dumville J, Wilkinson N, Taylor J, Thomas F, Goulden K, Vinod C, Green E, Waymont C, Rogers J, Grant A, Carter V, Heap H, Lomas C, Cooke P, Scarratt L, Hodgkiss T, Johnstone D, Johnson J, Allsop J, Rothwell J, Connolly K, Cherian J, Ridgway S, Coulding M, Savill H, Mccormick J, Clark M, Collins G, Jewers K, Keith S, Bowen G, Hargreaves J, Riley K, Rees A, Williams S, Dukes S, Goffe A, Mistry R, Chadwick J, Cocks S, Hull R, oftus A, Baird Y, Moore S, Greenslade S, Margalef J, Chadbourn I, Harris M, Clitheroe P, Connolly S, Hodgkinson S, Haydock H, Storr E, Cogley L, Natale S, Lovegrove W, Slack K, Nash D, Smith K, Walsh J, Guerdette A, Hill M, Taylor B, Sinclair E, Perry M, Debbarma M, Hewitt D, Sriram R, Power A, Cannon J, Devereaux L, Thompson A, Atkinson K, Royle L, Madine J, MacLean K. Does urinary cytology have a role in haematuria investigations? BJU International 2018, 123: 74-81. PMID: 30003675, PMCID: PMC6334509, DOI: 10.1111/bju.14459.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Transitional CellFalse Negative ReactionsFalse Positive ReactionsFemaleHematuriaHumansKidney NeoplasmsMaleMiddle AgedNeoplasm GradingNeoplasm StagingPredictive Value of TestsProspective StudiesTomography, X-Ray ComputedUltrasonographyUreteral NeoplasmsUrinary Bladder NeoplasmsUrineUrographyConceptsUpper tract urothelial cancerPositive urine cytologyAccuracy of urinary cytologyDiagnosis of bladder cancerUrine cytologyHigh-risk cancerNegative predictive valuePositive predictive valueBladder cancerHaematuria investigationsUrinary cytologyInvasive testingDiagnostic accuracy of urinary cytologyMuscle-invasive bladder cancerProspective observational study of patientsMulticentre prospective observational studyObservational study of patientsPredictive valueEndoscopic tumor resectionPositive cytology resultsUpper tract imagingHigh-risk diseaseOutcomes of patientsDiagnosed bladder cancerStudy of patientsNovel urinary biomarkers for the detection of bladder cancer: A systematic review
Tan W, Tan W, Tan M, Khetrapal P, Dong L, deWinter P, Feber A, Kelly J. Novel urinary biomarkers for the detection of bladder cancer: A systematic review. Cancer Treatment Reviews 2018, 69: 39-52. PMID: 29902678, DOI: 10.1016/j.ctrv.2018.05.012.Peer-Reviewed Original ResearchConceptsNegative predictive valuePositive predictive valueUrinary biomarkersBladder cancerReceiver operating characteristicRisk of biasPredictive valueNon-muscle invasive bladder cancer patientsBiomarkers investigated to dateInvasive bladder cancer patientsDetection of bladder cancerDiagnosis of bladder cancerSystematic reviewNovel urinary biomarkersBladder cancer patientsQUADAS-2 toolCase-control studyAssessed risk of biasSpecificity of biomarkersPositive test resultsSystematic searchUrinary cytologySurveillance cystoscopyComprehensive systematic reviewQUADAS-2MP06-06 DOES URINARY CYTOLOGY HAVE A ROLE IN HEMATURIA INVESTIGATIONS? RESULTS OF A PROSPECTIVE OBSERVATIONAL STUDY (DETECT I)
Tan W, Feber A, Dong L, Sarpong R, Rodney S, Khetrapal P, de Winter P, Jalil R, Williams N, Brew-Graves C, Kelly J, group D. MP06-06 DOES URINARY CYTOLOGY HAVE A ROLE IN HEMATURIA INVESTIGATIONS? RESULTS OF A PROSPECTIVE OBSERVATIONAL STUDY (DETECT I). Journal Of Urology 2018, 199: e54. DOI: 10.1016/j.juro.2018.02.198.Peer-Reviewed Original Research1012 What is the role of urinary cytology as part of haematuria investigations? Results of a prospective observational study (DETECT I)
Tan W, Feber A, Sarpong R, Jalil R, Khetrapal P, Rodney P, Dong L, Rezaee S, Wiliams N, Brew-Graves C, Kelly J. 1012 What is the role of urinary cytology as part of haematuria investigations? Results of a prospective observational study (DETECT I). European Urology Open Science 2018, 17: e1426. DOI: 10.1016/s1569-9056(18)31837-2.Peer-Reviewed Original Research