Multiregion sequencing of penile cancer to reveal distinct patterns of heterogeneous actionable mutations.
Rodney S, Tanic M, Barrett J, Amy W, de Winter P, Tan W, Khetrapal P, Dong L, Rezaee S, Freeman A, Nigam R, Malone P, Muneer A, Beck S, Feber A, Kelly J. Multiregion sequencing of penile cancer to reveal distinct patterns of heterogeneous actionable mutations. Journal Of Clinical Oncology 2017, 35: 4518-4518. DOI: 10.1200/jco.2017.35.15_suppl.4518.Peer-Reviewed Original ResearchLymph node metastasisPenile cancerCopy number changesNode metastasisIntra-tumor heterogeneityActionable mutationsCases of HPV infectionOutcome of metastatic diseaseHuman papillomavirus infectionPotential of immunotherapyTyrosine kinase inhibitorsInter-tumor heterogeneityMutation loadAcquisition of mutationsDeep whole-exome sequencingEarly eventWhole-exome sequencingHPV infectionMetastatic diseaseHuman papillomavirusPapillomavirus infectionClinical outcomesMultiregional sequencingMutated PIK3CAMetastatic tissues