2017
Multiregion sequencing of penile cancer to reveal distinct patterns of heterogeneous actionable mutations.
Rodney S, Tanic M, Barrett J, Amy W, de Winter P, Tan W, Khetrapal P, Dong L, Rezaee S, Freeman A, Nigam R, Malone P, Muneer A, Beck S, Feber A, Kelly J. Multiregion sequencing of penile cancer to reveal distinct patterns of heterogeneous actionable mutations. Journal Of Clinical Oncology 2017, 35: 4518-4518. DOI: 10.1200/jco.2017.35.15_suppl.4518.Peer-Reviewed Original ResearchLymph node metastasisPenile cancerCopy number changesNode metastasisIntra-tumor heterogeneityActionable mutationsCases of HPV infectionOutcome of metastatic diseaseHuman papillomavirus infectionPotential of immunotherapyTyrosine kinase inhibitorsInter-tumor heterogeneityMutation loadAcquisition of mutationsDeep whole-exome sequencingEarly eventWhole-exome sequencingHPV infectionMetastatic diseaseHuman papillomavirusPapillomavirus infectionClinical outcomesMultiregional sequencingMutated PIK3CAMetastatic tissues
2016
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
Feber A, Worth D, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R, Malone P, Tan W, Rodney S, Freeman A, Jameson C, Wilson G, Powles T, Beck S, Fenton T, Sharp T, Muneer A, Kelly J. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Cancer Research 2016, 76: 4720-4727. PMID: 27325650, PMCID: PMC5302160, DOI: 10.1158/0008-5472.can-15-3134.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingResequencing of candidate genesPenile cancerMiRNA-mediated gene silencingCytoplasmic P-bodiesCopy-number informationAnalysis of somatic alterationsSomatic mutation landscapeDevelopment of penile cancerPenile squamous cell carcinomaTargeted resequencingCandidate genesDNA methylationGene silencingHPV-negative diseaseP-bodiesRecurrent mutationsLandscape of alterationsAPOBEC mutational signaturesSquamous cell carcinomaGermline DNASomatic alterationsMutation dataMutational signaturesGenetic alterations
2015
Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Feber A, Arya M, de Winter P, Saqib M, Nigam R, Malone P, Tan W, Rodney S, Lechner M, Freeman A, Jameson C, Muneer A, Beck S, Kelly J. Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer. Clinical Cancer Research 2015, 21: 1196-1206. PMID: 25538261, PMCID: PMC4351916, DOI: 10.1158/1078-0432.ccr-14-1656.Peer-Reviewed Original ResearchMeSH KeywordsCell Transformation, NeoplasticCell Transformation, ViralCluster AnalysisComputational BiologyCpG IslandsDNA MethylationEpigenesis, GeneticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLymph NodesLymphatic MetastasisMaleNeoplasm MetastasisPapillomaviridaePapillomavirus InfectionsPenile NeoplasmsRepetitive Sequences, Nucleic AcidConceptsHead and neck squamous cell carcinomaCervical squamous cell carcinomaSquamous cell carcinomaPenile cancerHPV statusEpigenetic alterationsCell carcinomaMethylation variable positionsEpi-signatureLymph node metastases markerNeck squamous cell carcinomaHPV-driven malignanciesTumor supressor geneLymph node metastasisMarkers of metastasisPredictors of survivalGenome-wide methylation arrayHPV-induced tumorigenesisHPV infectionRare malignancyOverall survivalQ-MSPNode metastasisTumor tissuesHPV