A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces