2023
Network analysis of ecological momentary assessment identifies frustration as a central node in irritability
Tseng W, Naim R, Chue A, Shaughnessy S, Meigs J, Pine D, Leibenluft E, Kircanski K, Brotman M. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability. Journal Of Child Psychology And Psychiatry 2023, 64: 1212-1221. PMID: 36977629, PMCID: PMC10615387, DOI: 10.1111/jcpp.13794.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityEcological Momentary AssessmentFemaleFrustrationHumansIrritable MoodMaleMood DisordersConceptsEcological momentary assessment
2022
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDiffusion Tensor ImagingHumansLongitudinal StudiesWhite MatterConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interaction
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityChildFrustrationHumansIrritable MoodMood DisordersConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2020
Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityChildComorbidityHumansIrritable MoodMood DisordersConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorder
2019
Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes
Tsai FJ, Tseng WL, Yang LK, Gau SS. Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes. PLOS ONE 2019, 14: e0211873. PMID: 30730956, PMCID: PMC6366698, DOI: 10.1371/journal.pone.0211873.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxiety DisordersAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMood DisordersNeuropsychological TestsSleep Wake DisordersYoung AdultConceptsAttention-deficit/hyperactivity disorderDrug-naïve adultsChildhood attention-deficit/hyperactivity disorderPsychiatric comorbidityMedication treatmentHigh riskTreatment durationHyperactivity disorderSemi-structured psychiatric interviewCurrent medication treatmentHealthy adult controlsEffects of medicationLonger treatment durationShorter treatment durationAttention deficit hyperactivity disorderADHD inattentive subtypeMore comorbiditiesMedical recordsHealthy controlsMood disordersSleep disordersComorbiditiesPsychiatric interviewLower riskADHD subtypes
2018
A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2014
Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators
Gau SS, Tseng WL, Tseng WY, Wu YH, Lo YC. Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators. Psychological Medicine 2014, 45: 529-543. PMID: 25075643, DOI: 10.1017/s0033291714001664.Peer-Reviewed Original ResearchAdolescentAttention Deficit Disorder with HyperactivityCase-Control StudiesChildDiffusion Tensor ImagingExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsSchoolsTaiwanWhite MatterSymptoms of Attention-Deficit/Hyperactivity Disorder and Peer Functioning: a Transactional Model of Development
Tseng WL, Kawabata Y, Gau SS, Crick NR. Symptoms of Attention-Deficit/Hyperactivity Disorder and Peer Functioning: a Transactional Model of Development. Research On Child And Adolescent Psychopathology 2014, 42: 1353-1365. PMID: 24830516, DOI: 10.1007/s10802-014-9883-8.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityChildChild DevelopmentFemaleFriendsHumansInterpersonal RelationsMaleModels, PsychologicalPeer GroupRejection, PsychologyTaiwanConceptsHyperactivity/impulsivityPeer functioningPeer impairmentADHD symptomsPeer relationshipsAttention-deficit/hyperactivity disorderShort-term longitudinal studyChild ADHD symptomsVersion IV scaleChildren's peer relationshipsCross-lagged modelsNumber of friendshipsInattentive symptomsPeer rejectionTransactional interplayPeer acceptanceHyperactivity disorderPeer nominationsTransactional modelParent reportPhysical aggressionCommunity sampleInattentionNegative facetsImpulsivity
2013
Executive function as a mediator in the link between attention‐deficit/hyperactivity disorder and social problems
Tseng W, Gau S. Executive function as a mediator in the link between attention‐deficit/hyperactivity disorder and social problems. Journal Of Child Psychology And Psychiatry 2013, 54: 996-1004. PMID: 23574361, DOI: 10.1111/jcpp.12072.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildExecutive FunctionHumansMaleMemory, Short-TermNeuropsychological TestsPsychological TestsSocial AdjustmentSocial Behavior DisordersConceptsAttention-deficit/hyperactivity disorderExecutive functionADHD youthHyperactivity disorderEffects of ADHDCambridge Neuropsychological Test Automated BatteryAspects of EFSocial problemsExecutive function measuresSubgroups of youthCognitive processesADHD groupResponse inhibitionADHD symptomsADHD severityChild reportsYouthFunction measuresMemoryStrong linkSubtestsIQDisordersMeasuresDeficits
2012
Relations of Inattention and Hyperactivity/Impulsivity to Preadolescent Peer Functioning: The Mediating Roles of Aggressive and Prosocial Behaviors
Tseng WL, Kawabata Y, Gau SS, Banny AM, Lingras KA, Crick NR. Relations of Inattention and Hyperactivity/Impulsivity to Preadolescent Peer Functioning: The Mediating Roles of Aggressive and Prosocial Behaviors. Journal Of Clinical Child & Adolescent Psychology 2012, 41: 275-287. PMID: 22420707, DOI: 10.1080/15374416.2012.656556.Peer-Reviewed Original ResearchMeSH KeywordsAggressionAttention Deficit Disorder with HyperactivityChildFemaleHumansImpulsive BehaviorInterpersonal RelationsMalePeer GroupSex FactorsSocial BehaviorConceptsHyperactivity/impulsivityPeer functioningProsocial behaviorRelational aggressionPhysical aggressionPelham IV Rating ScaleRelation of inattentionMore physical aggressionStructural equation modelingPeer acceptancePeer nominationsPeer reportsParent reportMediating RoleFifth gradersInattentionImpulsivityEquation modelingAggressionAggressive behaviorFunctioningPeersDirect pathRating ScaleGirls
2011
Symptoms of Attention-Deficit/Hyperactivity Disorder and Social and School Adjustment: The Moderating Roles of Age and Parenting
Kawabata Y, Tseng WL, Gau SS. Symptoms of Attention-Deficit/Hyperactivity Disorder and Social and School Adjustment: The Moderating Roles of Age and Parenting. Research On Child And Adolescent Psychopathology 2011, 40: 177-188. PMID: 21858455, DOI: 10.1007/s10802-011-9556-9.Peer-Reviewed Original ResearchMeSH KeywordsAchievementAdaptation, PsychologicalAdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildEducational StatusFemaleHumansLinear ModelsMaleMaternal BehaviorParentingPeer GroupSocial AdjustmentStudentsTaiwanConceptsAttention-deficit/hyperactivity disorderChild's ageSchool adjustmentADHD symptomsAttention problemsHyperactivity disorderMaternal parentingAcademic performanceDevelopmental psychopathology perspectiveMaternal affectionSocial adjustment problemsNegative peer relationshipsOlder childrenPsychopathology perspectiveSocial adjustmentPeer relationshipsAdjustment problemsMaternal overprotectionModerating RoleParentingNinth gradeYoung childrenOverprotectionSocial problemsChildren
2007
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on Once-Daily Atomoxetine Hydrochloride in Taiwanese Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
Gau SS, Huang YS, Soong WT, Chou MC, Chou WJ, Shang CY, Tseng WL, Allen AJ, Lee P. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on Once-Daily Atomoxetine Hydrochloride in Taiwanese Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. Journal Of Child And Adolescent Psychopharmacology 2007, 17: 447-460. PMID: 17822340, DOI: 10.1089/cap.2006.0091.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic Uptake InhibitorsAppetiteAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityChildDouble-Blind MethodDrug Administration ScheduleFacultyFemaleHumansMaleNauseaParentsPropylaminesPsychiatric Status Rating ScalesSeverity of Illness IndexTaiwanTreatment OutcomeConceptsAttention-deficit/hyperactivity disorderPrimary efficacy measureEfficacy measuresDaily atomoxetineAdverse eventsADHD Rating Scale-IV-Parent VersionDrug-related serious adverse eventsHyperactivity disorderSecondary efficacy measuresSerious adverse eventsClinical Global ImpressionCarried-forward approachEnd of studyTreatment effect sizeAtomoxetine groupPlacebo groupTreat basisPediatric patientsGlobal ImpressionSafe treatmentClinical trialsInvestigator AdministeredEdition criteriaTreatment groupsMental disordersAssociation Between Sleep Problems and Symptoms of Attention-Deficit/Hyperactivity Disorder in Young Adults
Gau SS, Kessler RC, Tseng WL, Wu YY, Chiu YN, Yeh CB, Hwu HG. Association Between Sleep Problems and Symptoms of Attention-Deficit/Hyperactivity Disorder in Young Adults. Sleep 2007, 30: 195-201. PMID: 17326545, DOI: 10.1093/sleep/30.2.195.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttention Deficit Disorder with HyperactivityDemographyFemaleHumansMalePolysomnographyPrevalencePsychometricsSeverity of Illness IndexSleep Wake DisordersSurveys and QuestionnairesConceptsAttention-deficit/hyperactivity disorderAdult ADHD Self-Report ScaleADHD Self-Report ScaleSelf-report scalesADHD groupSleep problemsNocturnal sleep durationHyperactivity disorderYoung adultsSleep needNon-ADHD groupsProbable attention deficit/hyperactivity disorderGreater sleep needFirst-year college studentsSleep durationSleep-related problemsHyperactivity symptomsHyperactivity subscaleCommunity sampleInattentionPrior findingsSleep scheduleCollege studentsCross-sectional surveyChinese version