Signal Sequence Recognition in Cotranslational Translocation by Protein Components of the Endoplasmic Reticulum Membrane
Mothes W, Jungnickel B, Brunner J, Rapoport T. Signal Sequence Recognition in Cotranslational Translocation by Protein Components of the Endoplasmic Reticulum Membrane. Journal Of Cell Biology 1998, 142: 355-364. PMID: 9679136, PMCID: PMC2133054, DOI: 10.1083/jcb.142.2.355.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesBiological Transport, ActiveCross-Linking ReagentsDetergentsDogsEndoplasmic ReticulumFungal ProteinsIn Vitro TechniquesIntracellular MembranesMembrane LipidsMembrane ProteinsProlactinProtein BiosynthesisProtein PrecursorsRibosomesSaccharomyces cerevisiae ProteinsSEC Translocation ChannelsSignal Recognition ParticleSolutionsConceptsEndoplasmic reticulum membraneSignal sequenceProtein componentsReticulum membraneSignal sequence recognitionSequence recognitionProtein-protein interactionsPhotocross-linking experimentsTranslocation channelCotranslational insertionTranslocation componentsCotranslational translocationMembrane proteinsSecretory proteinsNative membranesBinding sitesBulk lipidsSpecific binding sitesProteinDetergent solutionSequenceLipidsMembraneTranslocationSites