1999
Stratified Randomization for Clinical Trials
Kernan W, Viscoli C, Makuch R, Brass L, Horwitz R. Stratified Randomization for Clinical Trials. Journal Of Clinical Epidemiology 1999, 52: 19-26. PMID: 9973070, DOI: 10.1016/s0895-4356(98)00138-3.Peer-Reviewed Original ResearchConceptsStratified randomizationSmall trialsInterim analysisActive-control equivalence trialsClinical factorsLarge trialsSuperiority trialSubgroup analysisClinical trialsTreatment responsivenessTreatment outcomesMEDLINE searchTreatment groupsStratification factorsEquivalence trialPrognosisTrialsRandomizationType ITheoretical benefitsImportance of stratificationStratificationSample sizeInvestigatorsPatients
1994
Gender difference in prognosis after transient cerebral ischemia or minor stroke
Kernan W, Horwitz R, Brass L, Viscoli C. Gender difference in prognosis after transient cerebral ischemia or minor stroke. Journal Of Stroke And Cerebrovascular Diseases 1994, 4: 148-154. PMID: 26486051, DOI: 10.1016/s1052-3057(10)80177-6.Peer-Reviewed Original ResearchTransient ischemic attackTransient cerebral ischemiaCrude relative riskMinor strokeRelative riskIschemic attackCerebral ischemiaCarotid transient ischemic attacksInitial transient ischemic attackRisk of strokeGender differencesEligible patientsComorbid illnessesPrognostic strataStrokeLarger studyStudy outcomesWomenStatistical significanceMenIschemiaPrognosisRiskEffect of genderDeath
1991
A methodological appraisal of research on prognosis after transient ischemic attacks.
Kernan W, Feinstein A, Brass L. A methodological appraisal of research on prognosis after transient ischemic attacks. Stroke 1991, 22: 1108-1116. PMID: 1926253, DOI: 10.1161/01.str.22.9.1108.Peer-Reviewed Original ResearchConceptsTransient ischemic attackTransient ischemiaIschemic attackEligible studiesAspects of prognosisObservational cohort studyPrognosis of patientsSubgroup of patientsAppropriate end pointsPeer-reviewed journalsCohort studyInception cohortOutcome ratesIndividual patientsDiagnostic criteriaPatientsOutcome riskIschemiaMultivariate analysisPrognosisEnd pointSubsequent strokeAdherencePredictive variablesStroke