2005
Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST)
Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST). American Journal Of Obstetrics And Gynecology 2005, 192: 387-393. PMID: 15695976, DOI: 10.1016/j.ajog.2004.08.017.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationEstrogen therapyCognitive declineNormal Mini-Mental State ExaminationDouble-blind trialSecondary stroke preventionTransient ischemic attackIschemic attackPostmenopausal womenStroke preventionRecent strokeStroke trialsCerebrovascular diseaseWomen's EstrogenEstradiol-17betaState ExaminationCognitive measuresEstrogenWomenNormal functionDomain measuresLess declineTherapyStrokeRiskDecline in Physical Performance Among Women With a Recent Transient Ischemic Attack or Ischemic Stroke
Kernan WN, Viscoli CM, Brass LM, Gill TM, Sarrel PM, Horwitz RI. Decline in Physical Performance Among Women With a Recent Transient Ischemic Attack or Ischemic Stroke. Stroke 2005, 36: 630-634. PMID: 15677573, DOI: 10.1161/01.str.0000155728.42847.de.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokePhysical performance testsPhysical performanceIschemic attackRecent transient ischemic attackRecent ischemic strokeRecurrent neurological eventsAbsence of recurrenceLong-term disabilityEstrogen therapyRecurrent strokePostmenopausal womenNeurological eventsClinical trialsPPT scoresBaseline scoresFunctional independenceStrokeSpecific interventionsSubsequent strokeWomenSustained declineScoresBaseline
2002
Clinical assessment of function among women with a recent cerebrovascular event: a self-reported versus performance-based measure.
Owens PL, Bradley EH, Horwitz SM, Viscoli CM, Kernan WN, Brass LM, Sarrel PM, Horwitz RI. Clinical assessment of function among women with a recent cerebrovascular event: a self-reported versus performance-based measure. Annals Of Internal Medicine 2002, 136: 802-11. PMID: 12044128, DOI: 10.7326/0003-4819-136-11-200206040-00008.Peer-Reviewed Original ResearchConceptsLong-term health outcomesRecent cerebrovascular eventsLevel of functionCerebrovascular eventsPerformance-based measuresHealth outcomesSelf-reported functional statusTransient ischemic attackProspective cohort studyPhysical performance testsSelf-report measuresIschemic attackPostmenopausal womenBarthel IndexCohort studyNonwhite ethnicityFunctional statusClinical assessmentMost womenHealth measuresClinical settingSubsequent strokeWomenOutcomesStroke
2001
A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke
Viscoli C, Brass L, Kernan W, Sarrel P, Suissa S, Horwitz R. A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke. New England Journal Of Medicine 2001, 345: 1243-1249. PMID: 11680444, DOI: 10.1056/nejmoa010534.Peer-Reviewed Original ResearchConceptsEstrogen replacement therapyEstrogen therapyNonfatal strokePostmenopausal womenIschemic strokeCerebrovascular diseasePlacebo-controlled trialTransient ischemic attackOccurrence of strokeRisk of deathIschemic attackFatal strokeMean followPlacebo groupSecondary preventionEstradiol groupFunctional deficitsClinical trialsObservational studyHigh riskWoman's riskTherapyStrokeWomenDeath
1998
Estrogen after ischemic stroke: Clinical basis and design of The Women's Estrogen for Stroke Trial
Kernan W, Brass L, Viscoli C, Sarrel P, Makuch R, Horwitz R. Estrogen after ischemic stroke: Clinical basis and design of The Women's Estrogen for Stroke Trial. Journal Of Stroke And Cerebrovascular Diseases 1998, 7: 85-95. PMID: 17895061, DOI: 10.1016/s1052-3057(98)80026-8.Peer-Reviewed Original ResearchIschemic strokeStroke trialsWomen's EstrogenSecondary stroke preventionStroke risk factorsTransient ischemic attackTime of strokeUse of estrogenEffectiveness of estrogenIschemic attackRecurrent strokeEstrogen usersPostmenopausal womenStroke preventionUterine bleedingEndometrial hyperplasiaAsymptomatic womenVaginal ultrasonographyUterine cancerRisk factorsImproved outcomesObservational studyTherapeutic effectClinical basisExclusion criteria