Featured Publications
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient population
2022
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigher serum MIF levelsHigh-expression MIF allelesRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphismsChange in covid-19 risk over time following vaccination with CoronaVac: test negative case-control study
Hitchings MDT, Ranzani OT, Lind ML, Dorion M, D'Agostini TL, de Paula RC, de Paula OFP, de Moura Villela EF, Scaramuzzini Torres MS, de Oliveira SB, Schulz W, Almiron M, Said R, de Oliveira RD, Vieira da Silva P, de Araújo WN, Gorinchteyn JC, Dean NE, Andrews JR, Cummings DAT, Ko AI, Croda J. Change in covid-19 risk over time following vaccination with CoronaVac: test negative case-control study. The BMJ 2022, 377: e070102. PMID: 35697361, PMCID: PMC9189440, DOI: 10.1136/bmj-2022-070102.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrazilCase-Control StudiesCOVID-19COVID-19 TestingCOVID-19 VaccinesHumansSARS-CoV-2VaccinationVaccinesConceptsSymptomatic COVID-19Negative case-control studyCase-control studyHospital admissionOdds ratioCOVID-19Series completionCovid-19 related hospital admissionReverse transcription polymerase chain reaction testingTranscription polymerase chain reaction testingSevere COVID-19 outcomesSARS-CoV-2 infectionPolymerase chain reaction testingInactivated whole virus vaccineDoses of CoronaVacAcute respiratory illnessTest-negative controlsWhole virus vaccineRelated hospital admissionsHealthcare worker statusConditional logistic regressionCOVID-19 outcomesCOVID-19 symptomsMunicipality of residenceSARS-CoV-2
2021
Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection
El-Khoury JM, Schulz WL, Durant TJS. Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection. The Journal Of Applied Laboratory Medicine 2021, 6: jfab030-. PMID: 33822964, PMCID: PMC8083453, DOI: 10.1093/jalm/jfab030.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionDays post-PCR positivitySARS-CoV-2-positive cohortRBD antibodiesAnti-SARSSerologic assaysSARS-CoV-2 serologic assaysDiagnostic sensitivityElecsys Anti-SARSCoV-2 SResidual clinical samplesAntibody testingRemote historyCoV-2S1-RBDUS populationLongitudinal assessmentInfection statusInfectionDiagnostic aidCohortTime pointsDiscrepant resultsClinical samplesPositivity
2020
Development and Validation of the Quick COVID-19 Severity Index: A Prognostic Tool for Early Clinical Decompensation
Haimovich AD, Ravindra NG, Stoytchev S, Young HP, Wilson FP, van Dijk D, Schulz WL, Taylor RA. Development and Validation of the Quick COVID-19 Severity Index: A Prognostic Tool for Early Clinical Decompensation. Annals Of Emergency Medicine 2020, 76: 442-453. PMID: 33012378, PMCID: PMC7373004, DOI: 10.1016/j.annemergmed.2020.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingEmergency Service, HospitalFemaleHumansMaleMiddle AgedOxygen Inhalation TherapyPandemicsPneumonia, ViralRespiratory InsufficiencyRetrospective StudiesRisk AssessmentSARS-CoV-2Severity of Illness IndexYoung AdultConceptsCOVID-19 Severity IndexQuick COVID-19 severity indexQuick Sequential Organ Failure AssessmentSequential Organ Failure AssessmentOrgan Failure AssessmentHours of admissionRespiratory failureSeverity IndexScoring systemSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Bedside scoring systemOxygen requirementPneumonia severity scoresHours of hospitalizationElixhauser Comorbidity IndexEmergency department patientsSeverity Index scoreCOVID-19 patientsSyndrome coronavirus 2Coronavirus disease 2019Failure AssessmentSimple scoring systemIndependent test cohortImpact of COVID-19 Pandemic on Laboratory Utilization
Durant TJS, Peaper DR, Ferguson D, Schulz WL. Impact of COVID-19 Pandemic on Laboratory Utilization. The Journal Of Applied Laboratory Medicine 2020, 5: 1194-1205. PMID: 32663258, PMCID: PMC7454564, DOI: 10.1093/jalm/jfaa121.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusClinical Laboratory ServicesClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingFacilities and Services UtilizationHumansIncidencePandemicsPneumonia, ViralPolymerase Chain ReactionReagent Kits, DiagnosticRetrospective StudiesSARS-CoV-2Specimen Handling