Interactions between multiple genetic determinants in the 5′ UTR and VP1 capsid control pathogenesis of chronic post-viral myopathy caused by coxsackievirus B1
Sandager MM, Nugent JL, Schulz WL, Messner RP, Tam PE. Interactions between multiple genetic determinants in the 5′ UTR and VP1 capsid control pathogenesis of chronic post-viral myopathy caused by coxsackievirus B1. Virology 2007, 372: 35-47. PMID: 18029287, PMCID: PMC2352162, DOI: 10.1016/j.virol.2007.10.020.Peer-Reviewed Original ResearchConceptsVP1 capsidLimb muscle weaknessGenetic determinantsClinical manifestationsMuscle weaknessAntibody responseViral determinantsCoxsackievirus B1Viral titersMiceUnderlying mechanismPathogenesisMyopathyMultiple genetic determinantsCurrent studyDifferent genetic backgroundsGenetic backgroundSecond strainFull attenuationDeterminantsMyositisTitersEnterovirusesComplex interplay