Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres
Cook BD, Dynek JN, Chang W, Shostak G, Smith S. Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres. Molecular And Cellular Biology 2002, 22: 332-342. PMID: 11739745, PMCID: PMC134233, DOI: 10.1128/mcb.22.1.332-342.2002.Peer-Reviewed Original ResearchConceptsTankyrase 2Tankyrase 1Telomeric complexTelomeric DNA-binding proteinAccess of telomerasePolymerase tankyrase 1DNA-binding proteinsSpecialized reverse transcriptaseEndogenous TRF1Telomere maintenanceTelomeric functionPrimary human cellsRelated homologsPARP domainTelomeric DNAHuman telomeresTRF1TelomeresHuman cellsADP-ribosylationPARP assaysRecent identificationTelomeraseReverse transcriptaseOverexpression