Blocking MHC class II on human endothelium mitigates acute rejection
Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1: e85293. PMID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.Peer-Reviewed Original ResearchClass II MHC moleculesCytotoxic T lymphocytesII MHC moleculesClass I MHC moleculesMHC moleculesI MHC moleculesEndothelial cellsAcute rejectionT cellsEffector memory T cellsT cell-mediated destructionAcute allograft rejectionCell-mediated destructionGraft endothelial cellsMemory T cellsAlloreactive cytotoxic T lymphocytesExperimental rodent modelsMajor histocompatibility complex moleculesSecondary lymphoid organsMHC class IIClass I major histocompatibility complex moleculesAllogeneic human lymphocytesHistocompatibility complex moleculesPrevents CD4Artery graft