Understanding Reduced Rotavirus Vaccine Efficacy in Low Socio-Economic Settings
Lopman BA, Pitzer VE, Sarkar R, Gladstone B, Patel M, Glasser J, Gambhir M, Atchison C, Grenfell BT, Edmunds WJ, Kang G, Parashar UD. Understanding Reduced Rotavirus Vaccine Efficacy in Low Socio-Economic Settings. PLOS ONE 2012, 7: e41720. PMID: 22879893, PMCID: PMC3412858, DOI: 10.1371/journal.pone.0041720.Peer-Reviewed Original ResearchConceptsLow socio-economic settingRotavirus vaccine efficacyVaccine efficacyRotavirus vaccineSevere diseaseNatural infectionImmunogenicity of vaccinationReduced vaccine efficacySevere rotavirus gastroenteritisReduced efficacyClinical trial resultsLow SES populationsRotavirus gastroenteritisVaccine performanceVaccination programImmune responseEpidemiological factorsVaccineVaccinationTrial resultsInfectionSES populationsEfficacyReduced protectionEfficacy declines