2022
Predicting the long-term impact of rotavirus vaccination in 112 countries from 2006 to 2034: A transmission modeling analysis
Kraay A, Steele M, Baker J, Hall E, Deshpande A, Saidzosa B, Mukaratirwa A, Boula A, Mpabalwani E, Kiulia N, Tsolenyanu E, Enweronu-Laryea C, Abebe A, Beyene B, Tefera M, Willilo R, Batmunkh N, Pastore R, Mwenda J, Antoni S, Cohen A, Pitzer V, Lopman B. Predicting the long-term impact of rotavirus vaccination in 112 countries from 2006 to 2034: A transmission modeling analysis. Vaccine 2022, 40: 6631-6639. PMID: 36210251, PMCID: PMC10351612, DOI: 10.1016/j.vaccine.2022.09.072.Peer-Reviewed Original ResearchConceptsRotavirus vaccinationRotavirus positivityVaccine introductionOne-dose scheduleTwo-dose seriesRotavirus burdenRotavirus casesRotavirus gastroenteritisHospital admissionMiddle-income countriesVaccine impactVaccinated individualsLong-term impactMortality burdenPercent reductionVaccinationLife yearsIndirect protectionLow-income countriesLong-term magnitudePositivityDeathBurdenYearsIntroduction Data
2018
Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction
Bennett A, Pollock L, Jere K, Pitzer V, Parashar U, Tate J, Heyderman R, Mwansambo C, French N, Nakagomi O, Iturriza-Gomara M, Everett D, Cunliffe N, Bar-Zeev N, Consortium F. Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction. Vaccine 2018, 36: 7142-7148. PMID: 29887320, PMCID: PMC6238204, DOI: 10.1016/j.vaccine.2018.04.030.Peer-Reviewed Original ResearchConceptsPost-vaccine introductionPrevalence of rotavirusVaccine effectivenessRotavirus prevalenceAcute gastroenteritisVaccine introductionRotavirus hospitalisationsVaccine coverageEfficacy estimatesAdjusted vaccine effectivenessRotavirus vaccine introductionYears of ageUse of vaccinesUnvaccinated infantsRotavirus diarrheaRotavirus diseaseUnvaccinated childrenReferral hospitalRoutine immunisationMalawian childrenSevere diarrheaStool samplesImportant causePoisson regressionHospitalisation
2016
In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13.
Hungerford D, Vivancos R, Read J, Pitzer V, Cunliffe N, French N, Iturriza-Gómara M. In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13. Eurosurveillance 2016, 21 PMID: 26794258, DOI: 10.2807/1560-7917.es.2016.21.2.30106.Peer-Reviewed Original ResearchConceptsGenotype distributionMultinomial multivariate logistic regressionRotavirus gastroenteritis casesRotavirus genotype distributionRoutine rotavirus vaccinationRotavirus vaccination programRotavirus-positive specimensMultivariate logistic regressionOdds of infectionAge of infectionRVGE casesUntypable genotypesRotavirus vaccinationRoutine vaccinationVaccine introductionVaccination programGastroenteritis casesEpidemiological changesGenotype surveillanceLogistic regressionCommon genotypeMicrobiological dataVaccinationSurveillance networkAge
2015
Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?
Pitzer VE, Bilcke J, Heylen E, Crawford FW, Callens M, De Smet F, Van Ranst M, Zeller M, Matthijnssens J. Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium? Scientific Reports 2015, 5: 18585. PMID: 26687288, PMCID: PMC4685644, DOI: 10.1038/srep18585.Peer-Reviewed Original ResearchConceptsVaccine introductionStrain-specific vaccine effectivenessVaccine-derived immunityRotavirus vaccine introductionVaccine-induced immunityAbsence of vaccinationRotavirus populationLarge-scale vaccinationDistribution of genotypesRotavirus gastroenteritisVaccine effectivenessHomotypic strainHospitalization dataPredominant rotavirusStrain replacementVaccinationVaccineImmunityInfectionViral populationsPopulationGastroenteritisYearsIncidenceRotavirus
2011
Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions
Pitzer VE, Patel MM, Lopman BA, Viboud C, Parashar UD, Grenfell BT. Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 19353-19358. PMID: 22084114, PMCID: PMC3228484, DOI: 10.1073/pnas.1110507108.Peer-Reviewed Original ResearchConceptsHeterotypic immunityCommon rotavirus genotypesPredominance of G1Impact of vaccinationVaccine-type strainsDistribution of genotypesPrevaccination levelsRotavirus incidenceRotavirus genotypesVaccinationGenotype distributionImmunityGenotype patternsRelative prevalenceVaccineIncidenceStrong immunityFrequency of cyclingDisease incidenceGenotypesStrong protectionNew strainG1HomotypicPrevalence