2024
TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolThe impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction
Hazan H, Ferrara M, Riley S, Li F, Zhou B, Kline E, Gibbs-Dean T, Karmani S, Tayfur S, Tek C, Keshavan M, Srihari V. The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction. Schizophrenia Research 2024, 264: 457-461. PMID: 38266513, PMCID: PMC10923115, DOI: 10.1016/j.schres.2024.01.022.Peer-Reviewed Original ResearchConceptsCoordinated specialty careDuration of untreated psychosisImpact of early detectionEarly detectionEarly detection campaignsSpecialty careAdjustment scoresCampaign yearDetection campaignsMediation analysisEffects of EDRegression modelsCareUntreated psychosisPositive symptomsGAFPatientsSalutary effects
2023
The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service
Ferrara M, Guloksuz S, Hazan H, Li F, Tek C, Sykes L, Riley S, Keshavan M, Srihari V. The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service. Schizophrenia Research 2023, 260: 198-204. PMID: 37688984, DOI: 10.1016/j.schres.2023.08.005.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesLength of stayUntreated psychosisPsychiatric hospitalizationFirst-episode servicesDuration of hospitalizationIncidence rate ratiosNon-affective psychosisNew Haven areaPoisson regression modelsPatient characteristicsHospitalization ratesRecent onsetMedical recordsHospitalizationEffect of durationNegative binomial regressionSpecialized treatmentPsychosisRate ratioBinomial regressionAdmissionDUPEnrollmentFirst yearTowards a youth mental health paradigm: a perspective and roadmap
Uhlhaas P, Davey C, Mehta U, Shah J, Torous J, Allen N, Avenevoli S, Bella-Awusah T, Chanen A, Chen E, Correll C, Do K, Fisher H, Frangou S, Hickie I, Keshavan M, Konrad K, Lee F, Liu C, Luna B, McGorry P, Meyer-Lindenberg A, Nordentoft M, Öngür D, Patton G, Paus T, Reininghaus U, Sawa A, Schoenbaum M, Schumann G, Srihari V, Susser E, Verma S, Woo T, Yang L, Yung A, Wood S. Towards a youth mental health paradigm: a perspective and roadmap. Molecular Psychiatry 2023, 28: 3171-3181. PMID: 37580524, PMCID: PMC10618105, DOI: 10.1038/s41380-023-02202-z.Peer-Reviewed Original ResearchConceptsMental disordersSevere mental disordersEarly intervention paradigmYears of ageMost mental disordersEarly diagnosisEmergence of psychopathologyClinical careTypical onsetProtective factorsBrain developmentMental healthDiagnosisDisordersHealth paradigmMental health paradigmPsychopathologyIntervention paradigmPathogenesisYoung peopleCarePreventionAberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity
Hauke D, Charlton C, Schmidt A, Griffiths J, Woods S, Ford J, Srihari V, Roth V, Diaconescu A, Mathalon D. Aberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 8: 1176-1185. PMID: 37536567, DOI: 10.1016/j.bpsc.2023.07.011.Peer-Reviewed Original ResearchConceptsPrecision-weighted prediction errorsHealthy control participantsCourse of schizophreniaCHR-P individualsLower-level precision-weighted prediction errorsControl participantsLow-level sensoryPredictive coding accountMismatch negativity paradigmHierarchical Gaussian FilterPrediction errorEarly psychosisSingle-trial analysisClinical high riskDouble deviantsMismatch negativityComputational mechanismsElectroencephalography amplitudeFuture psychosisComputational modelSchizophreniaPsychosisIndividualsParticipantsSensor spaceSampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES program
2022
DUP redux: Observations vs. experiments in early intervention (invited commentary on Nkire et al.)
Srihari V, Li F. DUP redux: Observations vs. experiments in early intervention (invited commentary on Nkire et al.). Schizophrenia Research 2022, 251: 46-48. PMID: 36565532, DOI: 10.1016/j.schres.2022.12.006.Peer-Reviewed Original ResearchPromoting the Success and Sustainability of Coordinated Specialty Care Teams in Ohio
Breitborde N, Parris C, Stearns W, Nawaz S, Seiber E, Hamilton S, Hefner J, Hogan T, Singh P, Knudsen K, Martt N, Srihari V, Cahill J, Jani A, Anagbonu F, Baughman C, Carpenter K, Dunivant C, Dunlap N, Guirgis H, Lazarus S, Moe A, Nguyen C, Wastler H, Montesano V. Promoting the Success and Sustainability of Coordinated Specialty Care Teams in Ohio. Psychiatric Services 2022, 74: 766-769. PMID: 36415991, DOI: 10.1176/appi.ps.20220126.Peer-Reviewed Original ResearchPredictability modulates neural response to eye contact in ASD
Naples AJ, Foss-Feig JH, Wolf JM, Srihari VH, McPartland JC. Predictability modulates neural response to eye contact in ASD. Molecular Autism 2022, 13: 42. PMID: 36309762, PMCID: PMC9618208, DOI: 10.1186/s13229-022-00519-0.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsNeural responsesAdult participantsAmplitude of N170Perception of gazeP300 event-related potentialExperiment twoN170 responseAnxiety symptomologyCognitive abilitiesNeural basisExperiment oneNeural processingASD sampleSpectrum disorderInterpersonal interactionsN170P300 responseAutistic womenEye contactEye trackingSocial interactionSocial contextSocial worldBrain–phenotype models fail for individuals who defy sample stereotypes
Greene AS, Shen X, Noble S, Horien C, Hahn CA, Arora J, Tokoglu F, Spann MN, Carrión CI, Barron DS, Sanacora G, Srihari VH, Woods SW, Scheinost D, Constable RT. Brain–phenotype models fail for individuals who defy sample stereotypes. Nature 2022, 609: 109-118. PMID: 36002572, PMCID: PMC9433326, DOI: 10.1038/s41586-022-05118-w.Peer-Reviewed Original ResearchConceptsBrain-phenotype relationshipsBrain functional organizationCognitive constructsIndividual differencesNeurocognitive measuresBrain activityNeurocognitive scoresStereotypical profileNeural targetsClinical interventionsNeural circuitsFunctional organizationIndividualsSuch relationshipsData-driven approachRelationshipStereotypesAbnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia
Goetzl EJ, Srihari VH, Mustapic M, Kapogiannis D, Heninger GR. Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia. The FASEB Journal 2022, 36: e22466. PMID: 35867070, PMCID: PMC9358927, DOI: 10.1096/fj.202200792rr.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesChannel proteinsExtracellular vesiclesGenome-wide association studiesMitochondrial ion channelsIon channel proteinsIndividual proteinsLeucine zipperAssociation studiesMitochondrial NaMitochondrial levelTransient receptor potential cation channelMitochondrial Ca2Ion channelsSequence studiesProteinMember B1Extracted proteinsCation channelsNeuronal functionΑ-1CMember 4Calcium homeostasisVesiclesStructural alterationsDistinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis
Han GT, Trevisan DA, Foss-Feig J, Srihari V, McPartland JC. Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis. Journal Of Autism And Developmental Disorders 2022, 53: 3636-3647. PMID: 35752729, PMCID: PMC10202012, DOI: 10.1007/s10803-022-05620-0.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSocial communication difficultiesSymptom networksCognitive-perceptual symptomsSpectrum disorderRepetitive behaviorsNeurodevelopmental conditionsCommunication difficultiesASDPotential treatment targetAutismSymptom network structureDiagnostic groupsTreatment targetsNetwork analysis approachHigh centralitySymptomatologySchizophreniaSymptomsOrganizationAdultsDisordersBayesian network analysisDifficultiesAnalysis approachReducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative
Ferrara M, Gallagher K, Yoviene Sykes LA, Markovich P, Li F, Pollard JM, Imetovski S, Cahill J, Guloksuz S, Srihari VH. Reducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative. Psychiatric Services 2022, 73: 1416-1419. PMID: 35652190, PMCID: PMC9715806, DOI: 10.1176/appi.ps.202100374.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesConfirmation of eligibilityEarly detection campaignsProportion of admissionsSpecialty care servicesQuality improvement interventionsQuality improvement initiativesLonger DUPMedian delayPoor outcomeUntreated psychosisTreatment accessPsychosis onsetPsychosis servicesCSC servicesCare servicesImprovement interventionsAdmissionImprovement initiativesDetection campaignsInterventionGreater vulnerabilityReferralPsychosisEarly Intervention Services for Schizophrenia: Looking Back and Looking Ahead
Srihari VH, Keshavan MS. Early Intervention Services for Schizophrenia: Looking Back and Looking Ahead. Schizophrenia Bulletin 2022, 48: 544-550. PMID: 35373302, PMCID: PMC9077409, DOI: 10.1093/schbul/sbac024.Peer-Reviewed Original ResearchToward an expanded and personalized approach to coordinated specialty care in early course psychoses
Keshavan MS, Ongur D, Srihari VH. Toward an expanded and personalized approach to coordinated specialty care in early course psychoses. Schizophrenia Research 2022, 241: 119-121. PMID: 35121436, DOI: 10.1016/j.schres.2022.01.016.Peer-Reviewed Original ResearchTiming of cannabis exposure relative to prodrome and psychosis onset in a community-based first episode psychosis sample
Kline ER, Ferrara M, Li F, D'Souza DC, Keshavan M, Srihari VH. Timing of cannabis exposure relative to prodrome and psychosis onset in a community-based first episode psychosis sample. Journal Of Psychiatric Research 2022, 147: 248-253. PMID: 35066293, PMCID: PMC8882157, DOI: 10.1016/j.jpsychires.2022.01.039.Peer-Reviewed Original ResearchConceptsCannabis exposurePublic health significancePsychosis onsetPsychotic disordersHealth significanceFirst-episode psychosis samplePsychosis sampleFirst exposureFirst-episode psychosis servicesWorse premorbid functioningAdverse prognostic factorAssociation of ageImpact of cannabisPsychosis PreventionSymptom onsetPrognostic factorsOverall incidenceEarly psychosis sampleConsecutive admissionsOverall burdenPsychotic illnessPsychosis servicesPsychosis symptomsGreater severityYounger age
2021
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH. Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder. Molecular Psychiatry 2021, 26: 7355-7362. PMID: 34471251, PMCID: PMC8872999, DOI: 10.1038/s41380-021-01268-x.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesMitochondrial proteinsCyclophilin DMitofusin 2Extracellular vesiclesFunctional mitochondrial proteinsElectron transport complexes INuclear respiratory factorOpen-reading frameNeuronal extracellular vesiclesNew drug targetsΓ coactivator 1αPenultimate enzymeTranscription factorsMajor depressive disorderLeucine zipperMyosin VIGene responsesMitochondrial biogenesisPotential biomarker proteinsProtein componentsSelective serotonin reuptake inhibitorsPPAR-γ coactivator 1αComplex IDrug targetsDopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia
Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A, Calkins ME, Cho YT, Fonteneau C, Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Wolf D, D’Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gray D, Lieberman J. Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia. Schizophrenia Bulletin 2021, 48: 199-210. PMID: 34423843, PMCID: PMC8781338, DOI: 10.1093/schbul/sbab095.Peer-Reviewed Original ResearchConceptsCortical dopamine neurotransmissionPositive allosteric modulationImportant therapeutic targetPF-06412562Dopaminergic receptorsD1R stimulationDA levelsTolerable dosesLevel of stimulationDopamine neurotransmissionReceptor stimulationTherapeutic targetPartial agonistCognitive deficitsBiased agonismFull agonismTarget engagementAllosteric modulationNew drugsStimulationPoor bioavailabilitySchizophreniaOptimal stimulationDrugsExpression levelsFirst help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care
Ferrara M, Guloksuz S, Mathis WS, Li F, Lin IH, Syed S, Gallagher K, Shah J, Kline E, Tek C, Keshavan M, Srihari VH. First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care. Social Psychiatry And Psychiatric Epidemiology 2021, 56: 1359-1369. PMID: 33948678, PMCID: PMC8319102, DOI: 10.1007/s00127-021-02090-0.Peer-Reviewed Original ResearchConceptsPsychosis onsetNon-affective psychosisPsychosis risk syndromeEarly detection effortsAversive eventsAversive pathwaysProdromal sampleClinical characteristicsAntipsychotic treatmentEffective treatmentSociodemographic characteristicsSpecialized treatmentPsychosisProdromeOnsetTreatmentStructured interviewsOverall functioningFamily membersMeasures of delayEpisodesNew HavenSemi-structured interviewsHelp seekersPathwayFace Perception Predicts Affective Theory of Mind in Autism Spectrum Disorder but Not Schizophrenia or Typical Development
Altschuler MR, Trevisan DA, Wolf JM, Naples AJ, Foss-Feig JH, Srihari VH, McPartland JC. Face Perception Predicts Affective Theory of Mind in Autism Spectrum Disorder but Not Schizophrenia or Typical Development. Journal Of Psychopathology And Clinical Science 2021, 130: 413-422. PMID: 34180705, PMCID: PMC8244155, DOI: 10.1037/abn0000621.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBenton Facial Recognition TestSchizophrenia spectrum disordersAffective ToM abilitiesTypical developmentSpectrum disorderAffective ToMToM difficultiesSocial cognitionToM abilitiesIndividual differencesBetter face recognition abilityFace recognition abilityFace recognition difficultiesTheory of mindFacial Recognition TestFull Scale IQFace perceptionAffective theoryRecognition difficultiesRecognition testEyes TestSocial dysfunctionRecognition abilityFace recognition