2022
Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia
Goetzl EJ, Srihari VH, Mustapic M, Kapogiannis D, Heninger GR. Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia. The FASEB Journal 2022, 36: e22466. PMID: 35867070, PMCID: PMC9358927, DOI: 10.1096/fj.202200792rr.Peer-Reviewed Original ResearchMeSH KeywordsCalciumDepressive Disorder, MajorExtracellular VesiclesGenome-Wide Association StudyHumansMembrane ProteinsMitochondrial ProteinsNeuronsSchizophreniaSodium-Calcium ExchangerConceptsNeuron-derived extracellular vesiclesChannel proteinsExtracellular vesiclesGenome-wide association studiesMitochondrial ion channelsIon channel proteinsIndividual proteinsLeucine zipperAssociation studiesMitochondrial NaMitochondrial levelTransient receptor potential cation channelMitochondrial Ca2Ion channelsSequence studiesProteinMember B1Extracted proteinsCation channelsNeuronal functionΑ-1CMember 4Calcium homeostasisVesiclesStructural alterations
2021
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH. Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder. Molecular Psychiatry 2021, 26: 7355-7362. PMID: 34471251, PMCID: PMC8872999, DOI: 10.1038/s41380-021-01268-x.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesMitochondrial proteinsCyclophilin DMitofusin 2Extracellular vesiclesFunctional mitochondrial proteinsElectron transport complexes INuclear respiratory factorOpen-reading frameNeuronal extracellular vesiclesNew drug targetsΓ coactivator 1αPenultimate enzymeTranscription factorsMajor depressive disorderLeucine zipperMyosin VIGene responsesMitochondrial biogenesisPotential biomarker proteinsProtein componentsSelective serotonin reuptake inhibitorsPPAR-γ coactivator 1αComplex IDrug targets