2002
Schizosaccharomyces pombe pfh1+Encodes an Essential 5′ to 3′ DNA Helicase That Is a Member of thePIF1 Subfamily of DNA Helicases
Zhou J, Qi H, Schulz V, Mateyak M, Monson E, Zakian V. Schizosaccharomyces pombe pfh1+Encodes an Essential 5′ to 3′ DNA Helicase That Is a Member of thePIF1 Subfamily of DNA Helicases. Molecular Biology Of The Cell 2002, 13: 2180-2191. PMID: 12058079, PMCID: PMC117634, DOI: 10.1091/mbc.02-02-0021.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsDNA HelicasesDNA PrimersDNA, MitochondrialDNA, RibosomalDNA-Binding ProteinsHumansMolecular Sequence DataPolycomb-Group ProteinsProteinsRestriction MappingSaccharomyces cerevisiae ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsTranscription FactorsConceptsS. pombe proteinPombe proteinsDNA helicaseHelicase activityTelomeric DNAS. cerevisiaeATPase/helicase activitySchizosaccharomyces pombe geneSole essential functionDNA helicase activityInvariant lysine residuePombe geneDNA helicasesMitochondrial DNADNA replicationMutant sporesCellular phenotypesHigh identityGenetic analysisEssential functionsSame phenotypePrototype memberHelicaseLysine residuesS phase
1994
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation
Schulz V, Zakian V. The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell 1994, 76: 145-155. PMID: 8287473, DOI: 10.1016/0092-8674(94)90179-1.Peer-Reviewed Original ResearchConceptsSubtelomeric genesDNA helicaseDe novoPif1 DNA helicaseYeast mutantsPif1 helicaseNew telomeresPif1 mutantsTelomere elongationTelomeric DNASubtelomeric regionsLittle homologyLoss of expressionChromosome breakageHelicaseGenesPIF1MutantsTelomeresNovoMutationsElevated frequencyExpressionCellsChromosomes