1997
Telomere Length Regulation by the Pif1 DNA Helicase
Monson E, Schulz V, Zakian V. Telomere Length Regulation by the Pif1 DNA Helicase. Pezcoller Foundation Symposia 1997, 97-110. DOI: 10.1007/978-1-4615-5365-6_7.Peer-Reviewed Original ResearchConventional replication machineryLinear eukaryotic chromosomesPif1 DNA helicaseProtein-DNA structuresConventional DNA polymerasesDNA polymeraseBroken chromosome endsUnique reverse transcriptaseEnds of chromosomesDNA replication enzymeCell cycle arrestEukaryotic chromosomesChromosome endsDNA helicaseLinear chromosomesUnreplicated DNAIntact chromosomesLength regulationReplication machineryTelomeric DNAReplication enzymesRNA primersCell cycleChromosomesStable maintenance
1996
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
Schulz V, Zakian V, Ogburn C, McKay J, Jarzebowicz A, Martin G, Edland S. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Human Genetics 1996, 97: 750-754. PMID: 8641691, DOI: 10.1007/bf02346184.Peer-Reviewed Original ResearchConceptsTRF lengthMean TRF lengthWerner syndromeDiabetes mellitusControl subjectsWS cellsReplicative declineSubset of cellsOcular cataractsGeriatric disordersPremature onsetMean lengthSenescent controlsReplicative capacitySenescent cellsEarly passagesAccelerated lossAccelerated rateChromosomal translocationsNormal somatic cellsWerner syndrome cellsReplicative potentialCellsCell cycle