2020
Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure
Dahmer M, Flori H, Sapru A, Kohne J, Weeks H, Curley M, Matthay M, Quasney M, Network B, Bateman S, Berg M, Borasino S, Bysani G, Cowl A, Bowens C, Faustino E, Fineman L, Godshall A, Hirshberg E, Kirby A, McLaughlin G, Medar S, Oren P, Schneider J, Schwarz A, Shanley T, Sorce L, Truemper E, Vander Heyden M, Wittmayer K, Zuppa A, Wypij D. Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. CHEST Journal 2020, 158: 1027-1035. PMID: 32275979, PMCID: PMC7478231, DOI: 10.1016/j.chest.2020.03.041.Peer-Reviewed Original ResearchConceptsAcute respiratory failureSP-D levelsPediatric ARDSRespiratory failureLung injurySurfactant protein DPlasma SPPrimary diagnosisPlasma SP-D levelsHigher oxygenation indexProtein DDays of intubationProspective cohort studyChronic lung diseaseRespiratory distress syndromeMulti-center studyYears of ageEnzyme-linked immunosorbentPediatric RiskPICU lengthOxygenation indexProlonged ventilationCohort studyMortality IIIDistress syndromeLong-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control
Biagas K, Hinton V, Hasbani N, Luckett P, Wypij D, Nadkarni V, Agus M, investigators H, Srinivasan V, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Asaro L, Coughlin-Wells K, French J, Natarajan A, Network T. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. The Journal Of Pediatrics 2020, 218: 57-63.e5. PMID: 31910992, PMCID: PMC7122648, DOI: 10.1016/j.jpeds.2019.10.055.Peer-Reviewed Original ResearchConceptsHealth-related qualityHigher-target groupGlycemic controlLife outcomesIll childrenPediatric QualityProspective longitudinal cohort studyIntensive care dischargeTarget glycemic controlTight glycemic controlLongitudinal cohort studyRisk of mortalityLack of benefitRespiratory failureCohort studyHospital dischargeInsulin titrationSecondary outcomesPrimary outcomeCare dischargeEligible childrenChild Behavior ChecklistOverall healthTotal healthVineland Adaptive Behavior Scales
2017
Tight Glycemic Control in Critically Ill Children
Agus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseCardiovascular Surgical ProceduresChildChild, PreschoolCritical IllnessFemaleGlucoseHospital MortalityHumansHyperglycemiaHypoglycemic AgentsInfantInfant, NewbornInsulinIntensive Care Units, PediatricIntention to Treat AnalysisLength of StayMalePostoperative PeriodConceptsHigher-target groupLower-target groupTight glycemic controlBlood glucose levelsGlycemic controlIll childrenGlucose levelsCardiac surgeryHealth care-associated infectionsICU-free daysVentilator-free daysCritically Ill ChildrenNormal blood glucose levelsIntensive care unitCare-associated infectionsSafety monitoring boardAverage glucose levelsHigh rateContinuous glucose monitoringIll adultsOrgan dysfunctionPrimary outcomeSevere hypoglycemiaTreat analysisCare unit