Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI.
Schönberg L, Mohamed A, Yu Q, Kwiatek R, Del Fante P, Calhoun V, Shan Z. Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI. Cerebrovascular And Brain Metabolism Reviews 2024, 271678x241270528. PMID: 39113421, DOI: 10.1177/0271678x241270528.Peer-Reviewed Original ResearchBlood oxygen level-dependentFunctional MRIME/CFS participantsHealthy controlsTask-based functional MRISymbol Digit Modalities TestFatigue syndromeRight postcentral gyrusTask functional MRIFMRI signal changesOxygen level-dependentMyalgic encephalomyelitis/chronic fatigue syndromeLeft primary motor cortexChronic fatigue syndromeTask blocksCognitive tasksPostcentral gyrusCognitive cortexBOLD adaptationNeurophysiological processesNeurophysiological mechanismsPrimary motor cortexLevel-dependentModal testingFatigue severityWhite-matter changes associated with a synergetic treatment for myalgic encephalomyelitis/chronic fatigue syndrome
Mohamed A, do Campo J, Del Fante P, Kwiatek R, Calhoun V, Shan Z. White-matter changes associated with a synergetic treatment for myalgic encephalomyelitis/chronic fatigue syndrome. Fatigue Biomedicine Health & Behavior 2024, ahead-of-print: 1-11. DOI: 10.1080/21641846.2024.2367921.Peer-Reviewed Original ResearchMyalgic encephalomyelitis/chronic fatigue syndromeLow-dose naltrexoneFatigue syndromeWhite-matter tractsPre-treatment baselineDebilitating chronic illnessDeficit symptomsME/CFS patientsDiffusion-weighted imaging dataReducing depressionTreating ME/CFSSymptom improvementFractional anisotropyOff-label treatmentWhite-matter changesNaltrexoneNICE guidelinesPost-treatmentSymptomsME/CFSNeuroimaging characteristicsClinical measuresChronic illnessControl groupRandomized controlled trials