Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua
Huang S, Chen C, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua. The Journal Of Pathology 2008, 214: 328-336. PMID: 18069648, DOI: 10.1002/path.2257.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCell MovementCells, CulturedChemokinesCulture Media, ConditionedDeciduaDendritic CellsEnzyme-Linked Immunosorbent AssayFemaleGene Expression ProfilingHumansImmunohistochemistryInterleukin-1betaOligonucleotide Array Sequence AnalysisPre-EclampsiaPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdReverse Transcriptase Polymerase Chain ReactionUp-RegulationConceptsFirst trimester decidual cellsDendritic cell infiltrationDendritic cellsDecidual cellsIL-1betaPre-eclampsiaCell infiltrationLeukocyte-free first trimester decidual cellsSpecialized antigen-presenting cellsDecidual dendritic cellsDendritic cell recruitmentPlacental bed biopsiesMature dendritic cellsPro-inflammatory cytokinesAntigen-presenting cellsMarked infiltratesMaternal morbidityPrimiparous patientsSystemic inflammationImmune toleranceSubsequent pregnancyBed biopsiesInflammatory milieuMacrophage infiltrationLeading cause