2022
Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages
Pantazi P, Clements T, Venø M, Abrahams V, Holder B. Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages. Journal Of Extracellular Vesicles 2022, 11: 12293. PMID: 36544271, PMCID: PMC9772496, DOI: 10.1002/jev2.12293.Peer-Reviewed Original ResearchConceptsNon-coding RNAsSmall non-coding RNAsY RNA fragmentsTRNA fragmentsRNA cargoExtracellular vesiclesFull-length tRNASmall RNA sequencingPrimary macrophagesSmall RNA cargoHigh relative abundanceHuman primary macrophagesRNA sequencingEnrichment analysisGene targetsGene expressionFirst comprehensive analysisSignaling pathwaysFunctional cargoRelative abundanceLow abundancePutative roleRNASnoRNAsInflammatory signaling pathways
2016
Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8
Gysler SM, Mulla MJ, Guerra M, Brosens JJ, Salmon JE, Chamley LW, Abrahams VM. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Molecular Human Reproduction 2016, 22: 465-474. PMID: 27029214, PMCID: PMC4941806, DOI: 10.1093/molehr/gaw027.Peer-Reviewed Original ResearchConceptsToll-like receptor 4IL-8 secretionAdverse pregnancy outcomesTrophoblast-derived exosomesHealthy pregnant controlsMiR-146aTrophoblast cellsMiR-155MiR-210Pregnancy complicationsAntiphospholipid syndromePregnant controlsTLR4 antagonistHTR8 cellsHuman first-trimester extravillous trophoblast cell lineFirst trimester extravillous trophoblast cell lineRelated adverse pregnancy outcomesAbsence of aPLMiR expression levelsPanel of miRsObstetric antiphospholipid syndromeExtravillous trophoblast cell lineToll-like receptor 8Pro-inflammatory effectsAmerican Heart Association