2013
Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration
Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 13416-13421. PMID: 23901114, PMCID: PMC3746860, DOI: 10.1073/pnas.1309810110.Peer-Reviewed Original ResearchConceptsHeart regenerationSTAT3 inhibitionCertain lower vertebratesZebrafish heart regenerationRibosome affinity purificationTranslational profilingProgram essentialLower vertebratesAffinity purificationPathway membersSTAT3-dependent mannerZebrafish cardiomyocytesCardiomyocyte proliferationAnimal growthInjury-induced proliferationDynamic inductionProliferationCardiomyocytesInjury responseRegenerationRln3aVertebratesCardiogenesisRNAInhibitionAn Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle
Gupta V, Gemberling M, Karra R, Rosenfeld GE, Evans T, Poss KD. An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle. Current Biology 2013, 23: 1221-1227. PMID: 23791730, PMCID: PMC3759223, DOI: 10.1016/j.cub.2013.05.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedGATA Transcription FactorsHeart VentriclesMorphogenesisMyocytes, CardiacZebrafishZebrafish ProteinsConceptsVentricular wallCortical layersNormal cardiac functionHeart regenerationHeart failureCardiac damageCardiac functionCardiac ventriclesExpression of GATA4Cellular mechanismsBiomechanical stressCardiomyocytesTransgenic inhibitionGATA4 activityMuscleVentricleZebrafish heart regenerationAdultsDynamic cellular mechanismsClonal analysisOrganismal growthDevelopmental programClonal plasticityJuvenile zebrafishGATA4
2012
Clonally dominant cardiomyocytes direct heart morphogenesis
Gupta V, Poss KD. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 2012, 484: 479-484. PMID: 22538609, PMCID: PMC3340018, DOI: 10.1038/nature11045.Peer-Reviewed Original ResearchConceptsStem cell populationVertebrate embryosVertebrate organsNew lineageClonal dominanceEmbryonic structuresClonal analysisTissue architectureCell populationsProliferative behaviorIndividual cardiomyocytesAdult formKey mechanismCardiomyocytesAdult cardiac structureCirculatory needsMorphogenesisLineagesEmbryosMaturesDominanceOrgansVariable sizeThick wallsLateral expansion