A Randomized Phase II Study of Daratumumab, Ixazomib, and Dexamethasone (DId, Arm A) Vs Daratumumab, Bortezomib and Dexamethasone (DVd) Followed By Daratumumab, Did (Arm B) in Newly Diagnosed Multiple Myeloma (DeRIVE) Study
Nooka A, Joseph N, Gupta V, Hofmeister C, Dhodapkar M, Burton B, Ahmed H, Linton D, Cortoos A, Lin T, Labotka R, Noga S, Kaufman J, Lonial S. A Randomized Phase II Study of Daratumumab, Ixazomib, and Dexamethasone (DId, Arm A) Vs Daratumumab, Bortezomib and Dexamethasone (DVd) Followed By Daratumumab, Did (Arm B) in Newly Diagnosed Multiple Myeloma (DeRIVE) Study. Blood 2023, 142: 4764. DOI: 10.1182/blood-2023-190871.Peer-Reviewed Original ResearchProgression-free survivalArm BPeripheral neuropathyInduction therapyPrimary endpointOverall survivalAutologous stem cell transplantGrade 3/4 peripheral neuropathyRandomized phase 2 studyTransplant-eligible myeloma patientsRandomized phase II studySecondary primary malignanciesTransplant-eligible patientsTransplant-ineligible patientsAdverse event profilePhase 2 studyPhase II studyStem cell transplantWinship Cancer InstituteInhibitor combination therapyStem cell collectionRegular clinical practiceHigh response rateMultiple myeloma studyMedian follow