2023
Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis
Liang R, Lin M, Menon V, Qiu J, Menon A, Breda L, Arif T, Rivella S, Ghaffari S. Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis. Blood Advances 2023, 7: 6873-6885. PMID: 37672319, PMCID: PMC10685172, DOI: 10.1182/bloodadvances.2022007655.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBeta-ThalassemiaCyclin-Dependent Kinase Inhibitor p21ErythropoiesisHumansSplenomegalyConceptsErythroid cell maturationErythroid cell survivalCell cycle inhibitor Cdkn1aFoxO3 target genesErythroid apoptosisFoxO3 transcription factorElevated reactive oxygen speciesΒ-globin geneCell maturationEmbryonic lethalityTranscription factorsTarget genesErythroid maturationReactive oxygen speciesMolecular networksMolecular mechanismsThalassemic erythropoiesisCell survivalProgenitor compartmentErythroid compartmentFOXO3Extramedullary erythropoiesisΒ-thalassemiaApoptosisHemoglobin production
2021
Erythroid enucleation: a gateway into a “bloody” world
Menon V, Ghaffari S. Erythroid enucleation: a gateway into a “bloody” world. Experimental Hematology 2021, 95: 13-22. PMID: 33440185, PMCID: PMC8147720, DOI: 10.1016/j.exphem.2021.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsCalciumCell NucleusChromatinColony-Forming Units AssayComputational BiologyCytokinesCytoskeletal ProteinsDNA-Binding ProteinsErythroblastsErythrocytesErythropoiesisIntercellular Signaling Peptides and ProteinsMammalsMiceMicroRNAsProto-Oncogene ProteinsReceptors, Thyroid HormoneRepressor ProteinsReticulocytesRho GTP-Binding ProteinsTranscription FactorsTransport VesiclesYolk SacConceptsTerminal erythroid maturationFormation of reticulocytesEnucleation processHematopoietic stem cellsTranscription factorsCytoskeletal proteinsErythroid maturationFascinating processOrthochromatic erythroblastsTerminal maturationRate-limiting stepStem cellsIntricate processMaturationRed blood cellsCellsRBC productionMicroRNAsProteinProduction ex vivoErythroblastsEx vivoMechanismDaily productionProduction