DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169
Menon VR, Ananthapadmanabhan V, Swanson S, Saini S, Sesay F, Yakovlev V, Florens L, DeCaprio JA, Washburn MP, Dozmorov M, Litovchick L. DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169. Cell Cycle 2019, 18: 531-551. PMID: 30773093, PMCID: PMC6464593, DOI: 10.1080/15384101.2019.1577525.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Cycle CheckpointsCell Line, TumorCRISPR-Cas SystemsDNA DamageDNA RepairGamma RaysGene EditingHumansMetabolic Networks and PathwaysMicePhosphorylationProtein BindingProtein Serine-Threonine KinasesProtein-Tyrosine KinasesRNA InterferenceRNA, Small InterferingTumor Suppressor p53-Binding Protein 1Ubiquitin-Protein LigasesConceptsDSB sitesDNA repair processesHomologous recombination repairDNA double-strand break repairDouble-strand break repairDNA damageDosage-dependent genesDosage of DYRK1AImportant protein kinasesUbiquitin-binding proteinsNon-homologous endOS cellsInhibition of DYRK1ADSB recruitmentRepair processDual-specificity tyrosinePhosphorylation sitesProteomic analysisBreak repairProtein kinaseRNF169Kinase 1ARecombination repairDependent genesMouse cells