2024
Addressing Disparities in Adolescent and Young Adult Oncology: A Multifaceted Approach.
Puthenpura V. Addressing Disparities in Adolescent and Young Adult Oncology: A Multifaceted Approach. Journal Of The National Comprehensive Cancer Network 2024, 22: 508-510. PMID: 39236751, DOI: 10.6004/jnccn.2024.7062.Peer-Reviewed Original Research
2023
Identifying Gender and Racial Bias in Pediatric Fellowship Letters of Recommendation: Do Word Choices Influence Interview Decisions?
Boolchandani H, Chen L, Elder R, Osborn R, Phatak U, Puthenpura V, Sheares B, Tiyyagura G, Amster L, Lee S, Langhan M. Identifying Gender and Racial Bias in Pediatric Fellowship Letters of Recommendation: Do Word Choices Influence Interview Decisions? The Journal Of Pediatrics 2023, 265: 113843. PMID: 37995931, DOI: 10.1016/j.jpeds.2023.113843.Peer-Reviewed Original ResearchUse of Immersive Virtual Reality Spaces to Engage Adolescent and Young Adult Patients With Cancer in Therapist-Guided Support Groups: Protocol for a Pre-Post Study
Marks A, Garbatini A, Hieftje K, Puthenpura V, Weser V, Fernandes C. Use of Immersive Virtual Reality Spaces to Engage Adolescent and Young Adult Patients With Cancer in Therapist-Guided Support Groups: Protocol for a Pre-Post Study. JMIR Research Protocols 2023, 12: e48761. PMID: 37943596, PMCID: PMC10667982, DOI: 10.2196/48761.Peer-Reviewed Original ResearchINTERNATIONAL REGISTERED REPORT IDENTIFIERYoung adult patientsSupport groupsAdult patientsYoung adultsMean attendance rateSupport group interventionNon-Hispanic blacksNon-Hispanic whitesOverall retention rateNon-Hispanic AsiansRare disease populationPeer support groupsFacilitated support groupBone marrow failureMedian ageCommon diagnosisPreliminary efficacyHematologic malignanciesDisease populationLife measuresPatientsFinal intervention sessionTransgender femalesPsychosocial supportOUTC-08. IMPLEMENTING SOCIAL DETERMINANT OF HEALTH DATA COLLECTION FOR PEDIATRIC, ADOLESCENT AND YOUNG ADULT NEURO-ONCOLOGY PATIENTS IN THE CLINICAL TRIAL CONSORTIA SETTING: PROGRESS AND CHALLENGES
Puthenpura V, Bona K, Cooney T, Coven S, Davidson T, Fouladi M, Kline C, Leary S, Mueller S, Green A, Marks A. OUTC-08. IMPLEMENTING SOCIAL DETERMINANT OF HEALTH DATA COLLECTION FOR PEDIATRIC, ADOLESCENT AND YOUNG ADULT NEURO-ONCOLOGY PATIENTS IN THE CLINICAL TRIAL CONSORTIA SETTING: PROGRESS AND CHALLENGES. Neuro-Oncology 2023, 25: i37-i37. PMCID: PMC10260067, DOI: 10.1093/neuonc/noad073.145.Peer-Reviewed Original ResearchNeuro-oncology patientsMulticenter clinical trialClinical trialsSocial determinantsSocioeconomic statusClinical Trials ConsortiumLong-term complicationsAYA cancer patientsAdverse social determinantsSocioeconomic status dataAdverse SDOHSurvival disparitiesMultidisciplinary careTherapy adherenceToxicity incidenceCancer patientsTrial therapyPersonal socioeconomic statusOutcome disparitiesTrial designSDOHPatientsHealth equityHealth data collectionTrialsAdjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium
Vieira A, Puthenpura V, Krailo M, Fallahazad N, Brougham M, Murray M, Frazier A, Lopes L, Pashankar F. Adjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium. Pediatric Blood & Cancer 2023, 70: e30426. PMID: 37243320, DOI: 10.1002/pbc.30426.Peer-Reviewed Original ResearchConceptsOvarian immature teratomaOverall survivalImmature teratomaPostoperative chemotherapyBrazilian patientsStage IIAdjuvant chemotherapyUK cohortGrade 1 diseaseGrade 3 patientsReceipt of chemotherapyMainstay of therapyValue of chemotherapyPrimary outcome measureClinical trial dataIT patientsEntire cohortUK patientsRelapse riskBrazilian cohortOutcome measuresPractice variationChemotherapyPatientsStage IPersonality Changes and Staring Spells in a 12-Year-Old Child: A Case Report Incorporating ChatGPT, a Natural Language Processing Tool Driven by Artificial Intelligence (AI)
Puthenpura V, Nadkarni S, DiLuna M, Hieftje K, Marks A. Personality Changes and Staring Spells in a 12-Year-Old Child: A Case Report Incorporating ChatGPT, a Natural Language Processing Tool Driven by Artificial Intelligence (AI). Cureus 2023, 15: e36408. PMID: 37090271, PMCID: PMC10115215, DOI: 10.7759/cureus.36408.Peer-Reviewed Original ResearchLow-grade gliomasIntracranial tumorsPersonality changesTreatment of LGGCentral nervous system tumorsMain presenting featuresBroad differential diagnosisNervous system tumorsPresenting featuresPediatric patientsCase reportSystem tumorsFavorable outcomeEndocrine conditionsMain symptomsDifferential diagnosisIntracranial neoplasmsBrain tumorsGrade gliomasEarly identificationSymptomsTumorsOlder childrenCommon typeNatural language processing toolsWords Used in Letters of Recommendation for Pediatric Residency Applicants: Demographic Differences and Impact on Interviews
Boolchandani H, Osborn R, Tiyyagura G, Sheares B, Chen L, Phatak U, Puthenpura V, Elder R, Lee S, Amster L, Langhan M. Words Used in Letters of Recommendation for Pediatric Residency Applicants: Demographic Differences and Impact on Interviews. Academic Pediatrics 2023, 23: 1614-1619. PMID: 36889506, DOI: 10.1016/j.acap.2023.02.012.Peer-Reviewed Original ResearchConceptsLetters of recommendationLetter writersCommunal termsNatural language processing applicationsLanguage processing applicationsApplicant genderInterview statusCommunal wordsWritersLanguageAgentic termsWordsGenderLetterSenior academic ranksRaceTextAgenciesEquitable approachResidency candidatesWomenSignificant associationEthnicitySignificant differencesInterviewsLoss to follow‐up of minorities, adolescents, and young adults on clinical trials: A report from the Children's Oncology Group
Puthenpura V, Ji L, Xu X, Roth M, Freyer D, Frazier A, Marks A, Pashankar F. Loss to follow‐up of minorities, adolescents, and young adults on clinical trials: A report from the Children's Oncology Group. Cancer 2023, 129: 1547-1556. PMID: 36813754, PMCID: PMC10357561, DOI: 10.1002/cncr.34701.Peer-Reviewed Original ResearchConceptsClinical trial participantsNon-Hispanic blacksTrial participantsHazard ratioOncology GroupClinical trialsMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelChildren's Oncology Group trialsProportional hazards regression modelsYoung adultsAdjusted hazard ratioChildren's Oncology GroupLong-term complicationsLong-term outcomesLog-rank testHazards regression modelsPediatric clinical trialsCancer clinical trial participantsLow socioeconomic status areasLong-term survivalEthnic minority patientsQuality of lifeLow socioeconomic statusNon-Hispanic whitesRisk of early death in adolescents and young adults with cancer: a population-based study
Berkman A, Andersen C, Hildebrandt M, Livingston J, Green A, Puthenpura V, Peterson S, Milam J, Miller K, Freyer D, Roth M. Risk of early death in adolescents and young adults with cancer: a population-based study. Journal Of The National Cancer Institute 2023, 115: 447-455. PMID: 36682385, PMCID: PMC10086632, DOI: 10.1093/jnci/djac206.Peer-Reviewed Original ResearchConceptsCentral nervous system tumorsNervous system tumorsEarly deathHematologic malignanciesSolid tumorsCancer typesInsurance statusSystem tumorsYoung adultsEnd Results registrySocioeconomic statusPopulation-based studyLow socioeconomic statusSupportive careHigh riskSociodemographic factorsAYAsTumorsHealth systemMalignancyCancerDeathRiskDeath percentageDiagnosis
2022
Intentional overdose of rivaroxaban and alcohol: A case report
Hamidi R, Sowa A, Halperin‐Goldstein S, Puthenpura V, Prozora S. Intentional overdose of rivaroxaban and alcohol: A case report. Pediatric Blood & Cancer 2022, 70: e29969. PMID: 36094312, DOI: 10.1002/pbc.29969.Peer-Reviewed Original ResearchNFB-05. A family-centered neurocutaneous syndrome clinic in the age of targeted therapies
Marks A, Antaya R, Balsamo L, Cardinale K, Cheron R, Frumberg D, Gentile V, Habib L, Puthenpura V, Zhang H. NFB-05. A family-centered neurocutaneous syndrome clinic in the age of targeted therapies. Neuro-Oncology 2022, 24: i129-i129. PMCID: PMC9165028, DOI: 10.1093/neuonc/noac079.469.Peer-Reviewed Original ResearchTuberous sclerosisPediatric patients 2 yearsYale-New Haven Children's HospitalInoperable plexiform neurofibromasPatients 2 yearsOwn side effectsYears of ageNeurofibromatosis type 1Multidisciplinary clinicNeurocutaneous syndromeChildren's HospitalPlexiform neurofibromaNeuro-oncologySide effectsSubspecialty consultationClinicType 1Young adultsSclerosisSyndromeHospitalTherapyAgeTreatmentClinical reasoning
2021
Disparities in the long-term survival of adolescent and young adult diffuse large B cell lymphoma survivors
Berkman A, Andersen C, Puthenpura V, Livingston J, Ahmed S, Cuglievan B, Hildebrandt M, Roth M. Disparities in the long-term survival of adolescent and young adult diffuse large B cell lymphoma survivors. Cancer Epidemiology 2021, 75: 102044. PMID: 34597882, PMCID: PMC8627460, DOI: 10.1016/j.canep.2021.102044.Peer-Reviewed Original ResearchConceptsLong-term survivalDLBCL survivorsLymphoma survivorsSurvival disparitiesDiffuse Large B-Cell Lymphoma SurvivorsNon-Hispanic black survivorsNon-Hispanic white survivorsWorse long-term survivalReduced long-term survivalEnd Results registryOverall survival patternsRace/ethnicityMedian followMale sexWhite survivorsOlder ageSurvivorsRacial disparitiesYoung adultsBlack survivorsSocioeconomic statusSurvivalSurvival patternsSexCurrent studyRadiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma
Puthenpura V, DeNunzio NJ, Zeng X, Giantsoudi D, Aboian M, Ebb D, Kahle KT, Yock TI, Marks AM. Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma. International Journal Of Particle Therapy 2021, 8: 58-65. PMID: 35127977, PMCID: PMC8768897, DOI: 10.14338/ijpt-21-00013.1.Peer-Reviewed Original ResearchRadiation necrosisAarskog-Scott syndromeProton beam radiation therapyHigh-dose dexamethasoneGross total resectionHyperbaric oxygen therapyPosterior fossa tumorsBeam radiation therapyGroup 3 medulloblastomaCancer predisposition syndromeRare genetic syndromeConcurrent vincristineTruncal weaknessRadiographic improvementClinical stabilizationOxygen therapyTotal resectionPathologic correlatesGait instabilityFossa tumorsRadiation therapyPossible associationSyndromeDevelopment of medulloblastomaPotential associationDisparities in Telehealth Utilization Within Pediatric Gastroenterology
Puthenpura V, Du N, Hauptman L, Porto AF. Disparities in Telehealth Utilization Within Pediatric Gastroenterology. Journal Of Pediatric Gastroenterology And Nutrition 2021, 73: 217-222. PMID: 34016884, DOI: 10.1097/mpg.0000000000003167.Peer-Reviewed Original ResearchConceptsPediatric gastroenterology practiceSignificant decreased oddsMultivariate logistic regressionDecreased oddsTelephone visitsGastroenterology practicePediatric GastroenterologyVideo visitsLogistic regressionDistressed Communities IndexAmbulatory care visitsAdjusted odds ratioConfidence intervalsUse of telemedicineNon-Hispanic whitesRace/ethnicityCare visitsClinic visitsRetrospective studyOdds ratioTelehealth utilizationPublic insurancePrivate insuranceTelemedicine programVisitsRacial/ethnic, socioeconomic, and geographic survival disparities in adolescents and young adults with primary central nervous system tumors
Puthenpura V, Canavan ME, Poynter JN, Roth M, Pashankar FD, Jones BA, Marks AM. Racial/ethnic, socioeconomic, and geographic survival disparities in adolescents and young adults with primary central nervous system tumors. Pediatric Blood & Cancer 2021, 68: e28970. PMID: 33704901, PMCID: PMC8221084, DOI: 10.1002/pbc.28970.Peer-Reviewed Original ResearchConceptsHazard of deathCentral nervous system tumorsNervous system tumorsRace/ethnicitySocioeconomic statusSystem tumorsMultivariate Cox proportional hazards modelNon-Hispanic black patientsNon-Hispanic white patientsPrimary central nervous system tumorsCox proportional hazards modelEnd Results (SEER) databaseRetrospective cohort studyPrimary CNS tumorsYoung adult patientsNeuro-oncology patientsProportional hazards modelLowest SES tertileLow socioeconomic statusNHB patientsAYA patientsHazard ratioNHW patientsAdult patientsCohort studyAssociation of Medicare and Medicaid Insurance Status with Increased Spine Surgery Utilization Rates
Benton J, Weiss B, Mowrey W, Yassari N, Wang B, De La Garza Ramos R, Gelfand Y, Castro-Rivas E, Puthenpura V, Yassari R, Yanamadala V. Association of Medicare and Medicaid Insurance Status with Increased Spine Surgery Utilization Rates. Spine 2021, 46: e939-e944. PMID: 33496542, DOI: 10.1097/brs.0000000000003968.Peer-Reviewed Original ResearchConceptsInsurance statusSpine surgeryMedicaid patientsSpine careRetrospective single-institution studyPrivate insuranceLogistic regressionMedicaid insurance statusMultivariable logistic regressionSingle-institution studyMultivariate logistic regressionPatient insurance statusConsecutive outpatientsTreatment recommendationsUninsured patientsWorse outcomesBACKGROUND DATAInclusion criteriaPatient's conditionPatientsSurgerySpine surgeonsNeurosurgical clinicSignificant associationSpine interventions
2020
Clinical Application of Digital Technologies in Adolescent and Young Adult Oncology Supportive Care
Puthenpura V, Marks AM. Clinical Application of Digital Technologies in Adolescent and Young Adult Oncology Supportive Care. Journal Of Adolescent And Young Adult Oncology 2020, 10: 127-130. PMID: 33296259, PMCID: PMC8182471, DOI: 10.1089/jayao.2020.0153.Peer-Reviewed Original ResearchSocial and legal implications of urine drug screen analysis in the neonate: A case of suspected specimen mishandling
Puthenpura V, Gueye-Ndiaye S, Joshi S, Puvabanditsin S, Carayannopoulos M. Social and legal implications of urine drug screen analysis in the neonate: A case of suspected specimen mishandling. Clinica Chimica Acta 2020, 511: 104-106. PMID: 33002470, DOI: 10.1016/j.cca.2020.09.032.Peer-Reviewed Original Research
2018
A Giant Gastroschisis Associated with Pulmonary Hypoplasia and Spinal Anomaly: A Case Report and a Literature Review
Puvabanditsin S, Burger R, Puthenpura V, Walzer L, Madubuko A, Minerowicz C, Mehta R. A Giant Gastroschisis Associated with Pulmonary Hypoplasia and Spinal Anomaly: A Case Report and a Literature Review. Case Reports In Pathology 2018, 2018: 8378769. PMID: 29854529, PMCID: PMC5954887, DOI: 10.1155/2018/8378769.Peer-Reviewed Case Reports and Technical NotesPulmonary hypoplasiaGiant gastroschisisCentral nervous system abnormalitiesGiant abdominal wallProlonged ventilator supportNervous system abnormalitiesLarge gastroschisisRespiratory insufficiencyVentilator supportPoor outcomeCase reportSystem abnormalitiesAbdominal wallSpinal anomaliesGastroschisisIsolated anomalyHypoplasiaAssociationLiterature reviewHerniationKyphoscoliosisInsufficiencyOmphaloceleAbnormalitiesLiverCongenital second-degree heart block and total anomalous pulmonary venous return associated with microduplication of 1q32.2
Puvabanditsin S, Puthenpura V, Gueye-Ndiaye S, Takyi M, Madubuko A, Walzer L, Mehta R. Congenital second-degree heart block and total anomalous pulmonary venous return associated with microduplication of 1q32.2. Annals Of Pediatric Cardiology 2018, 11: 194-196. PMID: 29922018, PMCID: PMC5963235, DOI: 10.4103/apc.apc_21_17.Peer-Reviewed Original ResearchPulmonary venous returnCardiac conduction defectsVenous returnHeart blockConduction defectsTotal anomalous pulmonary venous returnAnomalous pulmonary venous returnSecond-degree heart blockCongenital heart blockTerm female infantClinical featuresFemale infantOligonucleotide microarray analysisMicroarray analysisLAMB3 geneInterstitial duplication