2021
Latent brain state dynamics and cognitive flexibility in older adults
Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, Santini V, Henderson VW, Poston KL, Menon V. Latent brain state dynamics and cognitive flexibility in older adults. Progress In Neurobiology 2021, 208: 102180. PMID: 34627994, PMCID: PMC9585912, DOI: 10.1016/j.pneurobio.2021.102180.Peer-Reviewed Original ResearchConceptsBrain flexibilityOlder adultsBrain statesWhole-brain fMRI dataBrain state dynamicsHealthy older adultsCognitive flexibilityMemory taskCognitive inflexibilityNeurocomputational frameworkCognitive deficitsFMRI dataCognitive impairmentDynamic temporal propertiesInflexibilityAdultsTemporal propertiesPublic health concernCognitionSternbergElderly populationHealth concernTaskDeficitsImpairment
2017
Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacy
2009
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury. Journal Of Neuropathology & Experimental Neurology 2009, 68: 709-735. PMID: 19535999, PMCID: PMC2945234, DOI: 10.1097/nen.0b013e3181a9d503.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyProgressive tauopathyTau-immunoreactive neurofibrillary tanglesRepetitive brain traumaRepetitive head injuryProgressive neurological deteriorationCavum septum pellucidumSuperficial cortical layersMedial temporal lobeAstrocytic tanglesTau-immunoreactiveNeurological deteriorationDementia pugilisticaVentricular dilatationBrain traumaHead injurySeptum pellucidumNeurofibrillary degenerationMammillary bodiesNeurofibrillary tanglesDiffuse plaquesGait abnormalitiesMemory disturbanceTemporal lobe