2023
Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments
Fox H, Milivojevic V, Sinha R. Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments. Handbook Of Experimental Pharmacology 2023, 282: 127-161. PMID: 37592081, DOI: 10.1007/164_2023_687.Peer-Reviewed Original ResearchConceptsSubstance-using womenExogenous progesteroneBetter tailor treatmentsStress-induced cravingFace of stressSex-specific targetsGender-related differencesAdrenergic medicationsStress-related adaptationClinical trialsSpecific treatmentMedication developmentAlcohol consumptionCompulsive drugBiobehavioral mechanismsDrinking historyMedical problemsInnovative medicationsMedicationsNovel targetWomenGuanfacineProgesteroneTreatmentEfficacy
2018
7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development
Fox H, Milivojevic V, Blaine S, Sinha R. 7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development. 2018, 120-141. DOI: 10.1016/b978-0-12-813693-5.00007-1.Peer-Reviewed Original ResearchMedication developmentDrug useAlpha-2 adrenergic agonistsStress system dysregulationStress-induced cravingPreclinical dataSystem dysregulationAdrenergic agonistsDrug AdministrationEarly abstinenceBiobehavioral mechanismsBiobehavioral adaptationsDysphoric statesNovel targetSubstance useRelapseAbstinenceNew foodsSeries of studiesUrgent needMedicationsGuanfacineAgonistsHuman paradigm
2017
Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction
Milivojevic V, Sinha R, Fox H. Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction. 2017, 679-688. DOI: 10.1016/b978-0-12-803750-8.00069-5.ChaptersAnxiety pathophysiologyDrugs of abuseNeural stress systemsDrug-seeking behaviorEmotional controlDrug seekingRecent research findingsChronic stress stateNegative consequencesCocaine addictionCocaine dependenceStress systemResearch findingsLong-term agentsCocaine useDrug useAbuseGuanfacineCravingSeekingStress sensitivityAddictionAbilityRobust adaptationOwn laboratory
2015
Gender differences in stroop performance following guanfacine versus placebo in early abstinent cocaine-dependent men and women
Milivojevic V, Jayaram-Lindstrom N, Sinha R, Fox H. Gender differences in stroop performance following guanfacine versus placebo in early abstinent cocaine-dependent men and women. Drug And Alcohol Dependence 2015, 156: e152. DOI: 10.1016/j.drugalcdep.2015.07.415.Peer-Reviewed Original Research