Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse
Milivojevic V, Sinha R. Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse. Current Topics In Behavioral Neurosciences 2023, 1-25. PMID: 37985542, DOI: 10.1007/7854_2023_456.Peer-Reviewed Original ResearchAlcohol use disorderUse disordersHuman laboratory proceduresHuman laboratory modelRelapse riskAlcohol cuesBiobehavioral markersPsychobiological mechanismsStress dysregulationChronic alcohol useAlcohol relapseAlcohol useEffective interventionsNovel interventionsStress biologyReal worldDisordersInterventionCuesSignificant implicationsSignificant treatment challengeHigher relapse riskAUDRisk factorsAdaptationHypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression