2023
The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial
Eder M, Griffin M, Moreno-Villagomez J, Bellumkonda L, Maulion C, Asher J, Wilson F, Cox Z, Ivey-Miranda J, Rao V, Butler J, Borlaug B, McCallum W, Ramos-Mastache D, Testani J. The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial. International Journal Of Cardiology 2023, 381: 57-61. PMID: 37023862, DOI: 10.1016/j.ijcard.2023.04.002.Peer-Reviewed Original ResearchConceptsRight atrial pressureDiuretic efficiencyRight atrial areaDiuretic responseVenous congestionHeart failureCardio-renal interactionsLoop diuretic doseAcute heart failureRenal perfusion pressureLow cardiac outputMean arterial pressureRight ventricular systolicCongestive heart failureVentricular ejection fractionNet fluid outputForward flowDiuretic doseDiuretic resistanceTTE parametersCardiac indexVentricular systolicArterial pressureAtrial pressureEjection fraction
2021
FGF-23 (Fibroblast Growth Factor-23) and Cardiorenal Interactions
Ivey-Miranda JB, Stewart B, Cox ZL, McCallum W, Maulion C, Gleason O, Meegan G, Amatruda JG, Moreno-Villagomez J, Mahoney D, Turner JM, Wilson FP, Estrella MM, Shlipak MG, Rao VS, Testani JM. FGF-23 (Fibroblast Growth Factor-23) and Cardiorenal Interactions. Circulation Heart Failure 2021, 14: e008385. PMID: 34689571, PMCID: PMC8782627, DOI: 10.1161/circheartfailure.121.008385.Peer-Reviewed Original ResearchConceptsFGF-23Cardiorenal interactionsHeart failureDiuretic resistanceSodium avidityNeurohormonal activationMultivariable analysisDistal tubular sodium reabsorptionLoop diuretic doseTubular sodium reabsorptionGlomerular filtration rateCardiorenal dysfunctionDiuretic doseDiuretic treatmentNT-proBNPFractional excretionDiuretic administrationSodium reabsorptionPeak diuresisFiltration rateCare centerUrine samplingAnimal modelsSerum chlorideDisease severity
2020
Venous Congestion, Not Cardiac Index is Associated with Diuretic Resistance
Eder M, Griffin M, Fleming J, Gleason O, Meegan G, Ivey-Miranda J, Cox Z, Rao V, Testani J. Venous Congestion, Not Cardiac Index is Associated with Diuretic Resistance. Journal Of Cardiac Failure 2020, 26: s30-s31. DOI: 10.1016/j.cardfail.2020.09.095.Peer-Reviewed Original ResearchRight atrial pressureBaseline right atrial pressureAcute decompensated heart failureCardiac indexLow cardiac indexDiuretic efficiencyMin/m2Daily urine outputDiuretic resistanceUrine outputDiuretic responseVenous congestionDiuretic doseHeart failureDE groupHigher baseline right atrial pressureHigher right atrial pressureElevated right atrial pressureBaseline cardiac indexLoop diuretic doseDecompensated heart failureCongestive heart failureSubset of patientsGreater diuretic responseCardiorenal interactionsMechanisms of Diuretic Resistance Study: design and rationale
Cox ZL, Fleming J, Ivey‐Miranda J, Griffin M, Mahoney D, Jackson K, Hodson DZ, Thomas D, Gomez N, Rao VS, Testani JM. Mechanisms of Diuretic Resistance Study: design and rationale. ESC Heart Failure 2020, 7: 4458-4464. PMID: 32893505, PMCID: PMC7754741, DOI: 10.1002/ehf2.12949.Peer-Reviewed Original ResearchAcute decompensated heart failureDiuretic resistanceDiuretic responseUrine collectionCombination diuretic therapyLoop diuretic administrationLoop diuretic doseLoop diuretic resistanceDecompensated heart failureProspective patient cohortPhysical exam findingsSpot urine collectionADHF hospitalizationsDiuretic doseDiuretic therapyHF outcomesBaseline bloodCommon complicationPatient characteristicsProspective cohortHeart failureLoop diureticsDiuretic administrationUrine biomarkersExam findings
2019
Biomarkers of Intravascular and Extravascular Volume Overload: Associations with Parameters of Cardio-Renal Dysfunction
Gomez N, Stewart B, Barnett J, Thomas A, Wycallis E, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Mahoney D, Ivey-Miranda J, Griffin M, Rao V, Testani J. Biomarkers of Intravascular and Extravascular Volume Overload: Associations with Parameters of Cardio-Renal Dysfunction. Journal Of Cardiac Failure 2019, 25: s21. DOI: 10.1016/j.cardfail.2019.07.060.Peer-Reviewed Original ResearchIntravascular volume overloadCardio-renal dysfunctionExtravascular volume overloadNT-proBNPCA 125Volume overloadDiuretic efficiencyFluid overloadHeart failureUrinary kidney injury molecule-1Kidney injury molecule-1Higher NT-proBNPLoop diuretic dosePlasma NT-proBNPInjury molecule-1Median NT-proBNPCarbohydrate antigen 125Cardio-renal functionIntravascular fluid overloadExtravascular fluid overloadDiuretic doseIntravascular overloadLower eGFRSodium excretionUrine albuminUrine Growth Differentiation Factor-15 is Not an Independent Biomarker of Cardio-Renal Interactions in Patients with Heart Failure
Barnett J, Stewart B, Gomez N, Thomas A, Wycallis E, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Mahoney D, Ivey-Miranda J, Griffin M, Rao V, Testani J. Urine Growth Differentiation Factor-15 is Not an Independent Biomarker of Cardio-Renal Interactions in Patients with Heart Failure. Journal Of Cardiac Failure 2019, 25: s21-s22. DOI: 10.1016/j.cardfail.2019.07.063.Peer-Reviewed Original ResearchGrowth differentiation factor 15Plasma GDF-15GDF-15Heart failureDiuretic efficiencyDifferentiation factor 15Independent predictorsFactor 15Urinary cystatin C levelsCardio-renal interactionsLoop diuretic doseWorse kidney functionGlomerular filtration rateCystatin C levelsDiuretic doseNT-proBNPSodium excretionDiabetic patientsFractional excretionKidney functionPrognostic valueIndependent biomarkerOutpatient settingStress-responsive biomarkersFiltration rate