EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor
Hwang C, Giri V, Wilkinson J, Wright C, Wilkinson A, Cooney K, Duckett C. EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. Breast Cancer Research And Treatment 2007, 107: 235-242. PMID: 17453341, DOI: 10.1007/s10549-007-9542-7.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell Line, TumorDisease ProgressionDNA-Binding ProteinsEnhancer Elements, GeneticEnhancer of Zeste Homolog 2 ProteinEstradiolEstrogensHumansMicroscopy, FluorescencePolycomb Repressive Complex 2Polycomb-Group ProteinsProhibitinsReceptors, EstrogenRepressor ProteinsRNA InterferenceSignal TransductionTranscription FactorsTranscription, GeneticConceptsEstrogen-dependent transcriptionCellular differentiationReceptor activityPolycomb group (PcG) proteinsHistone methyltransferase activityDeregulated gene expressionActivity of EZH2Specific target genesNovel binding partnerBreast cancerEstrogen receptor corepressorPcG proteinsHistone modificationsTranscriptional repressionEstrogen-responsive genesTranscriptional corepressorGroup proteinsBreast cancer carcinogenesisZeste homolog 2Binding partnerTranscription factorsTarget genesHuman breast cancerEstrogen receptor activityMethyltransferase activity