A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes
Ritch E, Herberts C, Warner E, Ng S, Kwan E, Bacon J, Bernales C, Schönlau E, Fonseca N, Giri V, Maurice-Dror C, Vandekerkhove G, Jones S, Chi K, Wyatt A. A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes. Npj Precision Oncology 2023, 7: 27. PMID: 36914848, PMCID: PMC10011564, DOI: 10.1038/s41698-023-00366-z.Peer-Reviewed Original ResearchMetastatic prostate cancerDDR gene alterationsProstate cancerGene alterationsDDR deficiencyOngoing clinical trialsPlasma cell-free DNADNA damage repair defectsLiquid biopsy specimensMismatch repair deficiencyLeukocyte DNA samplesBladder cancer samplesCell-free DNABiopsy specimensBladder cancerClinical trialsTreatment benefitMetastatic prostate