2024
Health care utilization and behavior changes after workplace genetic testing at a large US health care system
Charnysh E, Pal S, Reader J, Uhlmann W, McCain S, Sanghavi K, Blasco D, Brandt R, Feero W, Ferber R, Giri V, Hendy K, Prince A, Lee C, Roberts J, consortium I, Crumpler N, Leader A, Mathews D, Ryan K, Spector-Bagdady K, Vogle A, Brothers K, Clayton E, Deverka P, Ellis T, Goldenberg A, Mockus S, Morton C, Rueter J, Witham B, Bessey E, Gordon E, Lee L, Roberts J, Saidi F. Health care utilization and behavior changes after workplace genetic testing at a large US health care system. Genetics In Medicine 2024, 26: 101160. PMID: 38733246, PMCID: PMC11566502, DOI: 10.1016/j.gim.2024.101160.Peer-Reviewed Original ResearchHealth behavior changeU.S. healthcare systemHealthcare utilizationIncreased riskAssociated with health behavior changesBehavioral changesHealthcare systemPromote health behavior changeGenetic testingImprove employee healthHeart diseaseSelf-reported dataLogistic regression analysisElectronic surveyMedication changesDescriptive statisticsHealthcarePGx resultsEmployee healthHealth implicationsRegression analysisHealthPGxWorkplaceCancerPD01-01 GERMLINE PATHOGENIC VARIANTS IN PATIENTS WITH PROSTATE CANCER: RESULTS FROM THE TECHNOLOGY-ENHANCED ACCELERATION OF GERMLINE EVALUATION FOR THERAPY (TARGET) STUDY
Loeb S, Gross L, Cheng H, Rivera A, Keith S, Byrne N, Nolasco T, Giri V. PD01-01 GERMLINE PATHOGENIC VARIANTS IN PATIENTS WITH PROSTATE CANCER: RESULTS FROM THE TECHNOLOGY-ENHANCED ACCELERATION OF GERMLINE EVALUATION FOR THERAPY (TARGET) STUDY. Journal Of Urology 2024, 211: e62. DOI: 10.1097/01.ju.0001009540.33579.43.01.Peer-Reviewed Original ResearchAddressing gaps in healthcare provider knowledge regarding germline testing for prostate cancer through development and testing of a virtual genetics board
Loeb S, Cheng H, Paller C, Weg E, Johnson J, Gross L, Keith S, Russo J, Hathaway F, Rivera A, Giri V. Addressing gaps in healthcare provider knowledge regarding germline testing for prostate cancer through development and testing of a virtual genetics board. Prostate Cancer And Prostatic Diseases 2024, 1-3. PMID: 38172199, DOI: 10.1038/s41391-023-00778-9.Peer-Reviewed Original Research
2022
Attitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate or Breast/Ovarian Cancer
Thakker S, Loeb S, Giri V, Bjurlin M, Matulewicz R. Attitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate or Breast/Ovarian Cancer. Urology Practice 2022, 10: 26-32. PMID: 37103438, DOI: 10.1097/upj.0000000000000352.Peer-Reviewed Original ResearchConceptsBreast/ovarian cancerHealth Information National Trends Survey 5Ovarian cancerProstate cancerGenetic testingCancer historyGenetic testing informationHistory of cancerHealthy U.S. adultsExposure of interestHealth care professionalsSelf-reported ratesEvidence-based informationPatient populationRepresentative sampleCare professionalsPatientsSecondary objectiveU.S. adultsCancerCommon sourceCategorical variablesSurvey 5Lack of awarenessCycle 4Guidelines on Germline Testing for Urologic Tumor Syndromes
Gomella P, Mark J, Giri V, Kelly W, Gomella L. Guidelines on Germline Testing for Urologic Tumor Syndromes. European Urology Focus 2022, 8: 670-673. PMID: 35803854, DOI: 10.1016/j.euf.2022.06.010.Peer-Reviewed Original ResearchConceptsGermline testingCurrent guidelinesTumor syndromeTreatment of patientsScreening of patientsAvailability of testingDifferent organ systemsGenitourinary cancersGenitourinary tractUrologic cancersTreatment decisionsPatientsOrgan systemsGene mutationsCancerGenetic mutationsSyndromeFamily membersTreatmentGuidelinesMutationsTestingUse of geneticsTractGermline testing and genetic counselling in prostate cancer
Russo J, Giri V. Germline testing and genetic counselling in prostate cancer. Nature Reviews Urology 2022, 19: 331-343. PMID: 35449224, PMCID: PMC9022414, DOI: 10.1038/s41585-022-00580-7.Peer-Reviewed Original ResearchConceptsProstate cancerCancer risk managementCancer riskGenetic testingHereditary cancer predisposition syndromesPre-test discussionUnique clinical featuresGermline pathogenic variantsPrecision medicineHealth care professionalsComplex management optionsAdditional cancer riskCancer predisposition syndromeHereditary cancer riskGenetic counsellingGermline testingMetastatic diseaseClinical featuresOptimal careMedical historyFamily historyPathogenic variantsPrecision therapyGene testingCancer
2021
Gaps in Public Awareness About BRCA and Genetic Testing in Prostate Cancer: Social Media Landscape Analysis
Loeb S, Massey P, Leader A, Thakker S, Falge E, Taneja S, Byrne N, Rose M, Joy M, Walter D, Katz M, Wong R, Selvan P, Keith S, Giri V. Gaps in Public Awareness About BRCA and Genetic Testing in Prostate Cancer: Social Media Landscape Analysis. JMIR Cancer 2021, 7: e27063. PMID: 34542414, PMCID: PMC8550715, DOI: 10.2196/27063.Peer-Reviewed Original ResearchProstate cancerBreast cancerGenetic testingHereditary cancer riskBreast cancer contentGermline testingPCa managementCancer riskHealth professionalsBRCACancerBreastcancerCancer contentProstatecancerPublic awarenessPopulation awarenessSearch termsPrecision medicineSubset of tweetsTotal numberTestingGreater reachBRCA1/2Genetic Testing Guidelines and Education of Health Care Providers Involved in Prostate Cancer Care
Mark J, McDougall C, Giri V. Genetic Testing Guidelines and Education of Health Care Providers Involved in Prostate Cancer Care. Urologic Clinics Of North America 2021, 48: 311-322. PMID: 34210487, DOI: 10.1016/j.ucl.2021.03.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGermline testingProstate cancerGenetic testing guidelinesFirst-line therapyCastration-resistant diseaseEarly-stage diseaseProstate cancer careHealth care providersGenetic test resultsPCA careCancer careCare providersScreening settingCancer implicationsPARP inhibitorsTesting guidelinesPossible roleDiseaseCareMenPractice strategiesOncologistsTestingTherapyCancerPhiladelphia Prostate Cancer Genetic Consensus Conference 2019 and implications for military medicine.
Peters C, Turner C, Chesnut G, Giri V, Gomella L, Shriver C, Dobi A. Philadelphia Prostate Cancer Genetic Consensus Conference 2019 and implications for military medicine. Canadian Journal Of Urology 2021, 28: 10659-10667. PMID: 34129457.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBarriers and facilitators of germline genetic evaluation for prostate cancer
Loeb S, Li R, Nolasco T, Byrne N, Cheng H, Becker D, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. The Prostate 2021, 81: 754-764. PMID: 34057231, DOI: 10.1002/pros.24172.Peer-Reviewed Original ResearchConceptsCoordination of careProstate cancerChronic Diseases frameworkGuideline-concordant careGermline testingMedical oncologistsPatient factorsPhysicians' knowledgePhysician educationRadiation oncologistsPractice settingsDisease frameworkThematic saturationGenetic counselingGenetic evaluationCareOncologistsRecent dataCancerConstant comparative methodInterview guidePhysiciansNumerous barriersQualitative studyInterview transcriptsBarriers and facilitators of germline genetic evaluation for prostate cancer.
Loeb S, Li R, Sanchez Nolasco T, Byrne N, Cheng H, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. Journal Of Clinical Oncology 2021, 39: 28-28. DOI: 10.1200/jco.2021.39.6_suppl.28.Peer-Reviewed Original ResearchCoordination of careProstate cancerGenetic testingChronic Diseases frameworkGuideline-concordant careGermline genetic testingMetastatic prostate cancerGenetic counselingGermline testingLocalized diseasePatient factorsMedical oncologistsTherapeutic optionsCancer screeningPhysicians' knowledgeCurrent guidelinesPhysician educationRecent approvalRadiation oncologistsPractice settingsCancerDisease frameworkThematic saturationProstate Cancer GeneticsGenetic evaluation
2020
Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC.
Szymaniak BM, Facchini LA, Giri VN, Antonarakis ES, Beer TM, Carlo MI, Danila DC, Dhawan M, George D, Graff JN, Gupta S, Heath E, Higano CS, Liu G, Molina AM, Paller CJ, Patnaik A, Petrylak DP, Reichert Z, Rettig MB, Ryan CJ, Taplin ME, Vinson J, Whang YE, Morgans AK, Cheng HH, McKay RR. Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC. JCO Oncology Practice 2020, 16: 811-819. PMID: 32986533, PMCID: PMC7735040, DOI: 10.1200/op.20.00431.Peer-Reviewed Original ResearchConceptsGermline genetic testingProstate cancerGenetic testingNumber of patientsCritical unmet needCurrent guidelinesTesting deliveryPatientsUnmet needPrecision oncologyGenomic testingGenetic counselingGenetics providersGenetic servicesClinical workflowCancerOncologyLimited accessWorking GroupGuidelinesStandardized systemProvidersTestingClinicHereditary Prostate Cancer
Giri V, Beebe-Dimmer J, Cooney K. Hereditary Prostate Cancer. 2020, 283-292. DOI: 10.1201/9781351187435-33.Peer-Reviewed Original ResearchHereditary prostate cancerProstate cancerCancer syndromesGenetic testing guidelinesMetastatic prostate cancerProstate cancer riskOvarian cancer syndromeHereditary cancer syndromesPrecision oncology studyClinical featuresLynch syndromeFatal cancerCancer riskGenetic predispositionHereditary breastCancerGenetic testingFamilial clusteringTesting guidelinesSyndromeGermline geneticsOncology studiesCancer susceptibilityGermline variationClinical application
2019
Introduction to the 2019 Philadelphia Prostate Cancer Consensus Program: 'Implementation of Genetic Testing for Inherited Prostate Cancer'.
Gomella L, Knudsen K, Giri V. Introduction to the 2019 Philadelphia Prostate Cancer Consensus Program: 'Implementation of Genetic Testing for Inherited Prostate Cancer'. Canadian Journal Of Urology 2019, 26: 1-4. PMID: 31629412.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInherited prostate cancerGenetic testingProstate cancerFirst International Consensus ConferenceKimmel Cancer CenterProstate cancer riskInternational Consensus ConferenceCancer ConsensusCancer CenterThomas Jefferson UniversityCancer riskConsensus meetingConsensus conferenceCancerFollowTestingGenetic education and practice considerations of non-genetic providers.
Giri V. Genetic education and practice considerations of non-genetic providers. Canadian Journal Of Urology 2019, 26: 44-45. PMID: 31629430.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsExploring Asian Indian views about cancer and participation in cancer research: an evaluation of a culturally tailored educational intervention
Giri V, Selvan P, Mohanty S, Lum R, Serrao S, Leader A. Exploring Asian Indian views about cancer and participation in cancer research: an evaluation of a culturally tailored educational intervention. Journal Of Community Genetics 2019, 11: 193-203. PMID: 31522341, PMCID: PMC7062964, DOI: 10.1007/s12687-019-00436-5.Peer-Reviewed Original ResearchCancer riskCancer risk assessmentAsian IndiansGenetic testingEducational interventionGenetic testing useCancer risk perceptionRisk factorsCancer incidenceCommunity settingsClinical researchMedical research studiesPilot studyTesting useCancerAI populationsRisk perceptionInterventionRisk assessmentUnited StatesCancer researchRiskFamily membersEducational effortsSignificant changesPrevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men
Chandrasekar T, Gross L, Gomella L, Hegarty S, Leong J, Giri V. Prevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men. European Urology Oncology 2019, 3: 291-297. PMID: 31278035, DOI: 10.1016/j.euo.2019.06.010.Peer-Reviewed Original ResearchConceptsHereditary cancer syndromesProstate cancerCancer syndromesFamily historyGermline mutationsExact testHereditary breastGenetic testingAfrican AmericansPCa family historyAfrican American patientsOvarian cancer syndromeCascade genetic testingFisher's exact testHereditary prostate cancerBRCA mutationsLynch syndromeOvarian cancerSyndromeCancerCascade testingDiverse cohortAA participantsSpectrum of genesFHxGermline Testing for Men With Prostate Cancer: Navigating an Expanding New World of Genetic Evaluation for Precision Therapy and Precision Management
Giri V, Hyatt C, Gomella L. Germline Testing for Men With Prostate Cancer: Navigating an Expanding New World of Genetic Evaluation for Precision Therapy and Precision Management. Journal Of Clinical Oncology 2019, 37: jco.18.02181. PMID: 30978156, DOI: 10.1200/jco.18.02181.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMP41-04 CASCADE TESTING OF MEN WITH PROSTATE CANCER IN FAMILIES WITH A SPECTRUM OF INHERITED CANCERS: IMPORTANCE OF ATTENTION TO RACE
Chandrasekar* T, Leong J, Gross L, Hegary S, Gomella L, Giri V. MP41-04 CASCADE TESTING OF MEN WITH PROSTATE CANCER IN FAMILIES WITH A SPECTRUM OF INHERITED CANCERS: IMPORTANCE OF ATTENTION TO RACE. Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000556117.44879.21.Peer-Reviewed Educational Materials
2018
Nutrition assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment.
Giri V, Bruneau M, Obeid E, Smaltz C, Milliron B. Nutrition assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment. Journal Of Clinical Oncology 2018, 36: 1519-1519. DOI: 10.1200/jco.2018.36.15_suppl.1519.Peer-Reviewed Original Research