2021
Gaps in Public Awareness About BRCA and Genetic Testing in Prostate Cancer: Social Media Landscape Analysis
Loeb S, Massey P, Leader A, Thakker S, Falge E, Taneja S, Byrne N, Rose M, Joy M, Walter D, Katz M, Wong R, Selvan P, Keith S, Giri V. Gaps in Public Awareness About BRCA and Genetic Testing in Prostate Cancer: Social Media Landscape Analysis. JMIR Cancer 2021, 7: e27063. PMID: 34542414, PMCID: PMC8550715, DOI: 10.2196/27063.Peer-Reviewed Original ResearchProstate cancerBreast cancerGenetic testingHereditary cancer riskBreast cancer contentGermline testingPCa managementCancer riskHealth professionalsBRCACancerBreastcancerCancer contentProstatecancerPublic awarenessPopulation awarenessSearch termsPrecision medicineSubset of tweetsTotal numberTestingGreater reachBRCA1/2
2017
Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation
Giri V, Obeid E, Gross L, Bealin L, Hyatt C, Hegarty S, Montgomery S, Forman A, Bingler R, Kelly W, Dicker A, Winheld S, Trabulsi E, Chen D, Lallas C, Allen B, Daly M, Gomella L. Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation. JCO Precision Oncology 2017, 1: 1-17. PMID: 34164591, PMCID: PMC8210976, DOI: 10.1200/po.16.00039.Peer-Reviewed Original ResearchFamily historyGenetic counselingMultigene testingEligibility criteriaPrecision therapyFH dataDNA repair genesReferral of menEarly-stage diseaseMultigene panel testingOvarian cancer syndromeStrong family historyCancer genetic evaluationStage/gradeRepair genesDetailed family historyPersonalized genetic counselingProstate cancer predispositionMetastatic diseaseCancer screeningMedical recordsProstate cancerBreast cancerMutation carriersHigh risk
2008
Substantial family history of prostate cancer in black men recruited for prostate cancer screening
Mastalski K, Coups E, Ruth K, Raysor S, Giri V. Substantial family history of prostate cancer in black men recruited for prostate cancer screening. Cancer 2008, 113: 2559-2564. PMID: 18816608, PMCID: PMC2626163, DOI: 10.1002/cncr.23862.Peer-Reviewed Original ResearchConceptsFH of PCaProstate Cancer Risk Assessment ProgramNational Health Interview SurveyProstate cancerFamily historyBlack menCancer Risk Assessment ProgramMore first-degree relativesSelf-reported family historyMore family historyProstate cancer screeningHigh-risk menMen ages 35First-degree relativesHealth Interview SurveyAge-matched sampleSuboptimal screeningCancer screeningBreast cancerScreening programAge 35Colon cancerPCa screeningRisk assessment programCancer
2007
EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor
Hwang C, Giri V, Wilkinson J, Wright C, Wilkinson A, Cooney K, Duckett C. EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. Breast Cancer Research And Treatment 2007, 107: 235-242. PMID: 17453341, DOI: 10.1007/s10549-007-9542-7.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell Line, TumorDisease ProgressionDNA-Binding ProteinsEnhancer Elements, GeneticEnhancer of Zeste Homolog 2 ProteinEstradiolEstrogensHumansMicroscopy, FluorescencePolycomb Repressive Complex 2Polycomb-Group ProteinsProhibitinsReceptors, EstrogenRepressor ProteinsRNA InterferenceSignal TransductionTranscription FactorsTranscription, GeneticConceptsEstrogen-dependent transcriptionCellular differentiationReceptor activityPolycomb group (PcG) proteinsHistone methyltransferase activityDeregulated gene expressionActivity of EZH2Specific target genesNovel binding partnerBreast cancerEstrogen receptor corepressorPcG proteinsHistone modificationsTranscriptional repressionEstrogen-responsive genesTranscriptional corepressorGroup proteinsBreast cancer carcinogenesisZeste homolog 2Binding partnerTranscription factorsTarget genesHuman breast cancerEstrogen receptor activityMethyltransferase activity