2019
Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression
Han M, Wei G, McManus CE, Hillier LW, Reinke V. Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression. BMC Genomics 2019, 20: 500. PMID: 31208332, PMCID: PMC6580472, DOI: 10.1186/s12864-019-5893-9.Peer-Reviewed Original ResearchConceptsHistone modificationsGerm cellsC. elegansC. elegans germ cellsGene expressionDevelopmental gene expressionGene expression mechanismsIsolation of nucleiGene regulationTranscriptome analysisChromatin immunoprecipitationGerm lineGenomic analysisDistinct genomic profilesRegulatory mechanismsRepressive mechanismsExpression mechanismElegansPure populationsGenomic profilesConsequent discoveriesCellsExpressionGenomeNucleus
2002
X-chromosome silencing in the germline of C. elegans.
Kelly WG, Schaner CE, Dernburg AF, Lee MH, Kim SK, Villeneuve AM, Reinke V. X-chromosome silencing in the germline of C. elegans. Development 2002, 129: 479-92. PMID: 11807039, PMCID: PMC4066729, DOI: 10.1242/dev.129.2.479.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansDisorders of Sex DevelopmentFemaleGene Expression Regulation, DevelopmentalGene SilencingGenes, ReporterGerm CellsGonadsHistonesImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMeiosisMethylationOligonucleotide Array Sequence AnalysisOocytesRecombinant Fusion ProteinsSpermatozoaTranscription, GeneticTransgenesX ChromosomeConceptsX chromosomeHistone modificationsC. elegansEarly meiosisX chromosome silencingNematode C. elegansGermline maintenanceNematode phylumHermaphroditic speciesChromatin organizationSex bodyXO malesTranscriptional competenceSex chromosomesTranscriptional activationTransgene arrayOocyte meiosisMeiosisChromosomesRepressive mechanismsElegansSpeciesHeterochromatinHermaphroditesGenome