2024
The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line
Paniagua N, Roberts C, Gonzalez L, Monedero-Alonso D, Reinke V. The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line. PLOS Genetics 2024, 20: e1011345. PMID: 38985845, PMCID: PMC11262695, DOI: 10.1371/journal.pgen.1011345.Peer-Reviewed Original ResearchPiRNA genesPiRNA clustersGenomic domainsC. elegans germ lineUpstream sequence transcription complexSmall RNA pathwaysGermline-specific expressionGlobal genome organizationPiRNA precursorsPiRNA pathwayChromosome IVGenome organizationRNA pathwaysChromatin stateTranscribed genesNucleosome positioningNucleosome densityGenome integrityTranscriptional regulationTranscription complexC. elegansPiRNAsGerm lineISW-1Nucleosomal environment
2014
The C. elegans SNAPc Component SNPC-4 Coats piRNA Domains and Is Globally Required for piRNA Abundance
Kasper DM, Wang G, Gardner KE, Johnstone TG, Reinke V. The C. elegans SNAPc Component SNPC-4 Coats piRNA Domains and Is Globally Required for piRNA Abundance. Developmental Cell 2014, 31: 145-158. PMID: 25373775, PMCID: PMC4223638, DOI: 10.1016/j.devcel.2014.09.015.Peer-Reviewed Original ResearchConceptsRNA genesPIWI-interacting RNA (piRNA) pathwayTransfer RNA genesSmall RNA genesDiscrete genomic regionsDNA-binding subunitSmall nuclear RNAPiRNA abundanceRNA pathwaysPiRNA genesChromatin organizationPiRNA clustersPiRNA expressionProtein complexesGenomic regionsCoordinated expressionNuclear RNAExpression environmentForeign sequencesGenesExpressionDomainPiRNAsLocalizationTransposon