2008
C. elegans Nucleostemin Is Required for Larval Growth and Germline Stem Cell Division
Kudron MM, Reinke V. C. elegans Nucleostemin Is Required for Larval Growth and Germline Stem Cell Division. PLOS Genetics 2008, 4: e1000181. PMID: 18725931, PMCID: PMC2515194, DOI: 10.1371/journal.pgen.1000181.Peer-Reviewed Original ResearchConceptsRibosome biogenesisGermline stem cell divisionLarval arrest phenotypeGerm line functionGermline stem cellsStem cell divisionCell growthNematode C. elegansN-terminal domainStem cellsExhibit reduced levelsCell cycle arrestArrest phenotypeNucleolar factorsC. elegansRRNA transcriptionGrowth defectNucleolar functionGerm lineCell divisionLarval growthTransgenic studiesBiogenesisStable expressionProliferative state
2002
X-chromosome silencing in the germline of C. elegans.
Kelly WG, Schaner CE, Dernburg AF, Lee MH, Kim SK, Villeneuve AM, Reinke V. X-chromosome silencing in the germline of C. elegans. Development 2002, 129: 479-92. PMID: 11807039, PMCID: PMC4066729, DOI: 10.1242/dev.129.2.479.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansDisorders of Sex DevelopmentFemaleGene Expression Regulation, DevelopmentalGene SilencingGenes, ReporterGerm CellsGonadsHistonesImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMeiosisMethylationOligonucleotide Array Sequence AnalysisOocytesRecombinant Fusion ProteinsSpermatozoaTranscription, GeneticTransgenesX ChromosomeConceptsX chromosomeHistone modificationsC. elegansEarly meiosisX chromosome silencingNematode C. elegansGermline maintenanceNematode phylumHermaphroditic speciesChromatin organizationSex bodyXO malesTranscriptional competenceSex chromosomesTranscriptional activationTransgene arrayOocyte meiosisMeiosisChromosomesRepressive mechanismsElegansSpeciesHeterochromatinHermaphroditesGenome