2011
C. elegans meg‐1 and meg‐2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival
Kapelle WS, Reinke V. C. elegans meg‐1 and meg‐2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Genesis 2011, 49: 380-391. PMID: 21305687, DOI: 10.1002/dvg.20726.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell ProliferationCell SurvivalDisorders of Sex DevelopmentEmbryo, NonmammalianEpistasis, GeneticFemaleGene Expression Regulation, DevelopmentalGerm CellsLuminescent ProteinsMaleRNA InterferenceRNA-Binding ProteinsTime FactorsConceptsGerm cell proliferationMeg 1Germ cellsEmbryonic primordial germ cellsTargeted RNAi screenPrimordial germ cellsCell proliferationGerm cell survivalGerm lineageP granulesRNAi screenLarval stagesMEG 2Cell survivalFamily membersMultiple pathwaysGerm cell degenerationPhenotypeSterilityProliferationOptimal proliferationCellsCell degenerationEmbryogenesisLineages
2008
MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans
Leacock SW, Reinke V. MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans. Genetics 2008, 178: 295-306. PMID: 18202375, PMCID: PMC2206079, DOI: 10.1534/genetics.107.080218.Peer-Reviewed Original ResearchConceptsP granulesMeg 1Germline developmentGerm lineageMEG 2Embryonic germ lineagesP-granule componentEmbryonic cell divisionGerm cell proliferationGLH-1Germ granulesSomatic lineagesCaenorhabditis elegansGermline segregationMis-segregationMaternal germlineCell divisionGerm cellsPhenotype increasesLineagesGermline defectsPGL-1MutantsProliferationGranules